Effect of pistachio consumption on plasma lipoprotein subclasses in pre-diabetic subjects

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
Pablo Hernández-AlonsoMònica Bulló

Abstract

Nuts have been demonstrated to improve several cardiovascular risk factors and the lipid profile in diabetic and pre-diabetic subjects. However, analysis of conventional serum lipid profiles does not completely explain the atherogenic risk associated with pre-diabetes. We therefore investigated whether chronic consumption of pistachio modifies the lipoprotein subclasses to a healthier profile in pre-diabetic subjects. Randomized cross-over clinical trial in 54 subjects with pre-diabetes. Subjects consumed a pistachio-supplemented diet (PD, 50% carbohydrates, 33% fat, including 57 g/d of pistachios daily) and a control diet (CD, 55% carbohydrates, 30% fat) for 4 months each, separated by a 2-week wash-out. Diets were isocaloric and matched for protein, fiber and saturated fatty acids. Nuclear magnetic resonance (NMR) was performed to determine changes in plasma lipoprotein subclasses. Small low-density lipoprotein particles (sLDL-P) significantly decreased after pistachio consumption compared to the nut-free diet (P = 0.023). The non-high-density lipoprotein particles (non-HDL-P i.e. VLDL-P plus LDL-P) significantly decreased under the PD compared to CD (P = 0.041). The percentage of sHDL-P increased by 2.23% after the PD compar...Continue Reading

Associated Clinical Trials

Citations

Mar 6, 2016·Nutrition Journal·Arianna CarughiDensie Webb
Dec 7, 2017·Nutrients·Rávila Graziany Machado de SouzaJoão Felipe Mota
Sep 29, 2015·The Cochrane Database of Systematic Reviews·Nicole MartinKaren Rees
Dec 16, 2017·Natural Product Research·Simona TerzoAntonella Amato
Jun 25, 2016·Nutrition Today·Pablo Hernández-AlonsoJordi Salas-Salvadó
Aug 15, 2019·Antioxidants·Marius Emil RusuDaniela-Saveta Popa
Jun 6, 2018·Frontiers in Physiology·Leandro R MarquesDaniela C Gonçalves
Oct 3, 2020·Nutrients·Jun Wern YauAmutha Ramadas
Mar 2, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Somayeh Hosseinpour-NiaziFereidoun Azizi
Jun 3, 2021·International Journal of Molecular Sciences·Teresa GervasiGiuseppina Mandalari

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