Effect of pitavastatin against expression of S100beta protein in the gerbil hippocampus after transient cerebral ischaemia

Acta Physiologica Scandinavica
Y MuramatsuT Araki

Abstract

We investigated the immunohistochemical alterations of S100beta-, S100-, glial fibrillary acidic protein (GFAP)- and isolectin B4-positive cells in the hippocampus after 5 min of transient cerebral ischaemia in gerbils. We also examined the effect of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor pitavastatin against neuronal damage in the hippocampal CA1 sector after ischaemia. Severe neuronal damage was observed in the hippocampal CA1 pyramidal neurons from 5 days after ischaemia. GFAP-positive cells increased gradually in the hippocampus from 5 days after ischaemia. Five and 14 days after ischaemia, significant increases in the number of GFAP-positive cells and isolectin B4-positive cells were observed in the hippocampal CA1 and CA3 sector. Mild increases in the number of S100 and S100beta-positive cells were observed in the hippocampal CA1 sector from 1 h to 2 days after ischaemia. Thereafter, S100beta-positive cells increased in the hippocampal CA1 sector after ischaemia, whereas S100-positive cells decreased in this region. In our double-labelled immunostainings, S100 and S100beta immunoreactivity was found in GFAP-positive astrocytes, but not in isolectin B4-positive microglia. Pharmacological study ...Continue Reading

References

Nov 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T MoriokaW J Streit
Jan 1, 1991·Glia·M E HattenC A Mason
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R H SelinfreundL J Van Eldik
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W S GriffinC Araoz
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L J Van EldikR A Jensen
May 1, 1982·Annals of Neurology·W A PulsinelliF Plum
Jan 1, 1995·Brain Research Bulletin·D B ZimmerW Song
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·R H ReevesD C Hilt
Jan 1, 1993·Glia·R B BanatiG W Kreutzberg
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·M EndresJ K Liao
Feb 6, 1999·Journal of the American College of Cardiology·W H KaesemeyerR W Caldwell
May 13, 1999·Brain Research. Molecular Brain Research·D LiuI A Simpson
Jun 5, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Toru MatsuiTakao Asano
Oct 24, 2002·Neurological Research·R KurosakiT Araki
Apr 5, 2003·Drug News & Perspectives·Yasuko Muramatsu, Tsutomu Araki

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Citations

Nov 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Masayuki KatsumotoKazuaki Chayama
Apr 9, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthias Endres
Feb 3, 2007·Journal of Neurochemistry·Toru NakazawaKohji Nishida
May 28, 2016·Journal of Neurochemistry·Ingrid MoralesManuel Rodriguez
Jun 23, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Toshiki HimedaTsutomu Araki

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