PMID: 8948502Aug 1, 1996Paper

Effect of pituitary and ovarian hormones on human melanocytes in vitro

Pigment Cell Research
K MaedaY Tomita

Abstract

Normal human melanocytes in culture became enlarged and dendritic after a 2-day incubation with either the pituitary (beta-MSH, a potent analog of alpha-MSH, ACTH, FSH and LH) or the ovarian (estradiol, estriol and progesterone) hormones. Under the same experimental conditions, pituitary hormones also increased both the tyrosinase activity and tyrosinase-related protein-1 (TRP-1) while ovarian hormones increased TRP-1 but not tyrosinase activity. The results suggest that pituitary and ovarian hormones possibly induce hyperpigmentation of the skin by stimulating the melanogenesis in epidermal melanocytes, and that estradiol and progesterone may be involved in the pathogenesis of melasma (chloasma) usually developing between early adulthood and menopause in which a high concentration of serum ovarian hormones was maintained.

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Citations

Jun 11, 2008·Archives of Dermatological Research·Man-Jau ChangTsong-Min Chang
Apr 2, 1998·Pigment Cell Research·S J HedleyS Macneil
Jun 14, 2005·Expert Opinion on Therapeutic Targets·M J Thornton
Jan 31, 2012·Journal of the American Academy of Dermatology·Yong Hyun JangEun-So Lee
Sep 17, 2011·Journal of the American Academy of Dermatology·Vaneeta M Sheth, Amit G Pandya
May 25, 2010·Journal of Pediatric and Adolescent Gynecology·Ioannis BiliatisAris Antsaklis
Aug 25, 2009·Contraception·Christine WiedemannCarola Berking
Jun 3, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·J P OrtonneW Westerhof
Mar 9, 2006·Skinmed·Craig G Burkhart
Apr 2, 2008·International Journal of Cosmetic Science·Z WangT Zhang
Mar 1, 2012·Journal of Cosmetic Dermatology·Mitsuo NakamaSatoru Nakata
Nov 14, 2006·Journal of the American Academy of Dermatology·Aditya K GuptaSusan Taylor
Dec 15, 2015·Photodermatology, Photoimmunology & Photomedicine·Keiichi HiramotoEiichi Mafune
Dec 11, 2002·Experimental Dermatology·M J Thornton
Sep 25, 2017·Clinical and Experimental Dermatology·S HandaN Sachdeva
Feb 3, 2018·International Journal of Endocrinology·Fabricio Ivan BusoliniFabian Heber Mohamed
Sep 24, 2004·Physiological Reviews·Andrzej SlominskiJacobo Wortsman
Aug 1, 2006·Endocrine Reviews·Ulrich OhnemusRalf Paus
Aug 19, 2016·Molecular and Cellular Biochemistry·Maristela Oliveira PoletiniAna Maria de Lauro Castrucci

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