Effect of plantar subcutaneous administration of bergamot essential oil and linalool on formalin-induced nociceptive behavior in mice

Biomedical Research
Soh KatsuyamaHitoshi Nakamura

Abstract

This study investigated the effect of bergamot essential oil (BEO) or linalool, a major volatile component of BEO, on the nociceptive response to formalin. Plantar subcutaneous injection of BEO or linalool into the ipsilateral hindpaw reduced both the first and late phases of the formalin-induced licking and biting responses in mice. Plantar subcutaneous injection of BEO or linalool into the contralateral hindpaw did not yield an antinociceptive effect, suggesting that the antinociceptive effect of BEO or linalool in the formalin test occurred peripherally. Intraperitoneal and plantar subcutaneous injection pretreatment with naloxone hydrochloride, an opioid receptor antagonist, significantly attenuated both BEO- and linalool-induced antinociception. Pretreatment with naloxone methiodide, a peripherally acting opioid receptor antagonists, also significantly antagonized the antinociceptive effects of BEO and linalool. Our results provide evidence for the involvement of peripheral opioids in antinociception induced by BEO and linalool. These results suggest that activation of peripheral opioid receptors may play an important role in reducing formalin-induced nociception.

References

Oct 1, 1992·Pain·A TjølsenK Hole
Apr 1, 1996·The Journal of Investigative Dermatology·M WintzenB A Gilchrest
Apr 17, 1999·European Journal of Pharmacology·T SatoK Kisara
Jun 22, 1999·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E ElisabetskyD O Souza
Dec 7, 2000·Journal of Pharmaceutical and Biomedical Analysis·P DugoG Dugo
Jun 18, 2002·European Journal of Pharmacology·Tanya Lewanowitsch, Rodney J Irvine
Jan 22, 2003·European Journal of Pharmacology·Alessandra T PeanaProto Pippia
Feb 18, 2003·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A T PeanaM D L Moretti
Feb 6, 2004·European Journal of Pharmacology·Alessandra T PeanaProto Pippia
Dec 14, 2005·Life Sciences·Alessandra T PeanaM Graziella De Montis
Jan 2, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Luigi A MorroneGiacinto Bagetta
Jun 27, 2008·Neuroscience Letters·Patrícia Aparecida BatistaAdair Roberto Soares Dos Santos
Jul 18, 2009·International Review of Neurobiology·Laura BerliocchiMaria Tiziana Corasaniti
Jul 18, 2009·International Review of Neurobiology·Tsukasa SakuradaShinobu Sakurada
Jan 23, 2010·Fitoterapia·Giacinto BagettaMaria Tiziana Corasaniti
May 11, 2010·The Journal of Pain : Official Journal of the American Pain Society·Patricia Aparecida BatistaAdair R S Santos
Oct 12, 2010·Pharmacology, Biochemistry, and Behavior·Tsukasa SakuradaShinobu Sakurada
Feb 10, 2012·Phytotherapy Research : PTR·Hossein HosseinzadehBibi Marjan Razavi
Jul 14, 2012·Biomedical Research·Soh KatsuyamaHitoshi Nakamura

❮ Previous
Next ❯

Citations

Apr 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laura RombolàLuigi Antonio Morrone
Dec 26, 2016·Peptides·Richard J Bodnar
Dec 22, 2016·Basic & Clinical Pharmacology & Toxicology·Salvatore Chirumbolo, Geir Bjørklund
Dec 14, 2017·International Journal of Molecular Sciences·Rita de Cássia da Silveira E SáDamião Pergentino de Sousa
Jul 7, 2018·International Journal of Molecular Sciences·Noura S Dosoky, William N Setzer
Mar 10, 2018·Current Medicinal Chemistry·Damiana ScuteriLuigi Antonio Morrone
Sep 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Laura RombolàLuigi Antonio Morrone
Apr 15, 2020·International Journal of Molecular Sciences·Laura RombolàLuigi Antonio Morrone
Apr 4, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Ramakanta LamichhaneHyun-Ju Jung
Jul 10, 2019·International Journal of Molecular Sciences·Damiana ScuteriMaria Tiziana Corasaniti
Mar 19, 2021·Frontiers in Pharmacology·Damiana ScuteriMaria Tiziana Corasaniti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.