Effect of plasma exchange on hepatocyte oxidative stress, mitochondria function, and apoptosis in patients with acute fatty liver of pregnancy

Artificial Organs
Wanxin TangPing Fu

Abstract

Acute fatty liver of pregnancy (AFLP) is an uncommon but clinically severe hepatopathy, and reactive oxygen species (ROS)-mediated mitochondrial apoptosis may be its key pathogenesis. Traditional therapy is inadequate for patients with severe conditions so the application of plasma exchange (PE) has been attempted. The present study aims to determine whether or not PE can lessen injuries to hepatocytes by ameliorating ROS and mitochondrial functions. Thirteen patients with AFLP were included in the experimental group, while fifteen patients made up the case-control group. PE was applied to patients in the PE group once a day for 1-3 days. Cultured hepatocytes were treated with serum or replacement fluid from patients and controls, respectively. Malondialdehyde, superoxide dismutase (SOD), mitochondrial membrane potential (MMP), caspase-3, caspase-9, and apoptosis of hepatocytes were measured. The clinical details and prognoses were also assessed. Patients in the experimental group had shorter durations of hepatic function recovery, intensive care unit (ICU) stay, and hospitalization than those in the case-control group, although both groups showed the same mortality. PE could induce the production of SOD, inhibit the production...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Dec 1, 1975·The American Journal of Pathology·J W EiseleE A Smuckler
Jan 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S A OcknerM G Peters
Aug 8, 1985·The New England Journal of Medicine·M M Kaplan
Dec 19, 1985·The New England Journal of Medicine·J G Bova, S Schenker
Jul 1, 1983·Transfusion·G W Buffaloe, F G Heineken
Feb 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W R TreemD M Turnbull
Apr 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S GrimbertD Pessayre
Nov 15, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S P PereiraR Williams
Aug 28, 1998·Science·D R Green, J C Reed
Mar 22, 2001·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·M OkamotoT Akizawa
May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Defeng Wu, Arthur I Cederbaum
Oct 31, 2002·The Journal of Biological Chemistry·Defeng Wu, Arthur I Cederbaum
Feb 26, 2004·American Journal of Obstetrics and Gynecology·Julie S MoldenhauerBaha Sibai
Jun 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jochen WuergesKristina Djinovic Carugo
Sep 15, 2004·Journal of Chemical Neuroanatomy·Takashi Momoi
Feb 9, 2005·Experimental Neurology·Munjal M Acharya, Surendra S Katyare
May 20, 2005·American Journal of Obstetrics and Gynecology·Michael F FesenmeierBaha M Sibai
Jan 19, 2006·The Journal of Biological Chemistry·Heather K LambAlastair R Hawkins
Jun 2, 2006·Clinical Science·Thais Martins de LimaRui Curi
Jul 29, 2006·Journal of Gastroenterology and Hepatology·Sathish Kumar NatarajanKunissery A Balasubramanian
Dec 6, 2006·The Journal of Experimental Medicine·Silvia CampelloAntonella Viola
Dec 15, 2006·World Journal of Gastroenterology : WJG·Jamal-A Ibdah
Feb 6, 2007·International Journal of Obstetric Anesthesia·T L GregoryA De Silva
Feb 13, 2007·Trends in Cardiovascular Medicine·Christopher A Papaharalambus, Kathy K Griendling
Mar 14, 2007·Pediatric Emergency Care·Joel B Cochran, Joseph D Losek
Mar 22, 2007·Expert Opinion on Therapeutic Targets·Georg Häcker, Stefan A Paschen
Apr 28, 2007·World Journal of Gastroenterology : WJG·Katsutoshi NaruseMasatoshi Makuuch
Apr 28, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A G RajasriJ Mitchell
Dec 21, 2007·Gut·C E EapenG Chandy
Jul 18, 2008·Journal of Clinical Apheresis·James N MartinJoe C Files
Nov 3, 2009·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Kalpana S VoraGeeta P Parikh
Dec 25, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sathish Kumar NatarajanKunnissery A Balasubramanian
Apr 13, 2010·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·M A Rockx, W F Clark

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Citations

Feb 21, 2013·Case Reports in Obstetrics and Gynecology·Mohammad Reza Seyyed Majidi, Jamshid Vafaeimanesh
Mar 6, 2013·Artificial Organs·Paul S Malchesky
Jan 5, 2013·Acta Biochimica Et Biophysica Sinica·Qiukai EJi Zuo
May 14, 2016·Chinese Medical Journal·Yan-Ping ZhangRong Zhou
Nov 15, 2019·Clinical Obstetrics and Gynecology·David B NelsonF Gary Cunningham
Jun 11, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Qiang GaoXin Qu
Feb 6, 2021·Obstetrics and Gynecology·David B NelsonF Gary Cunningham
Mar 27, 2021·Clinical Case Reports·Mohammed AabdiBrahim Housni

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis