PMID: 2572Dec 1, 1975

Effect of plasma [K+] on the DC potential and on ion distributions between CSF and blood

Journal of Applied Physiology
S W Bledsoe, A H Mines

Abstract

Keeping the arterial pH at 7.4 and PaCO2 at 40 mmHg in eight anesthetized dogs, we acutely raised plasma potassium concentration from 3.4 to 8.2 meq/1, then allowed it to decay back to control levels. The cerebrospinal fluid (CSF)-blood electrical potential difference (pd) increased 13.2 mV per 10-fold increase in plasma [K+]. Again keeping arterial pH at 7.4 and PaCO2 at 40 mmHg, we elevated plasma [K+] in four dogs from 3.3 to 8.0 meq/1 and maintained this level for 6 h. We found 1) that the PD increased from a control value of +1.3 to +8.9mV, showing no tendency to decay over the 6 h; and 2) that the change in PD did not affect the distribution of Na+, K+, H+, Cl-, or HCO3- between blood and CSF over the 6 h. These results suggest that under these conditions the PD between CSF and blood may play no effective role in determining the distributions of these charged species by 6 h. These results are contrasted with recent findings which suggest that H+ and HCO3- are distributed according to passive forces between CSF and blood.

Citations

May 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·E SørensenH Rask-Andersen
Dec 1, 1982·Pflügers Archiv : European journal of physiology·H R Ahmad, H H Loeschcke
Jun 30, 2009·Pharmacotherapy·Aaron M CookJimmi Hatton
Jul 28, 1977·The New England Journal of Medicine·A J BergerJ W Severinghaus

Related Concepts

Carbonic Acid Ions
Diastolic Blood Pressure
Cations, Monovalent
Cerebrospinal Fluid
Canis familiaris
Electrophysiology (Science)
Hydrogen-Ion Concentration
Parenteral Infusion
Potassium
Slow-K

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