PMID: 11333849May 3, 2001Paper

Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells

The American Journal of Clinical Nutrition
T Koga, M Meydani

Abstract

Flavonoids may exert their health benefit in cardiovascular disease by modulating monocyte adhesion in the inflammatory process of atherosclerosis. Most in vitro studies used forms of flavonoids present in food rather than forms that appear in plasma after ingestion. We tested the effects of plasma metabolites of (+)-catechin and quercetin on the modulation of monocyte adhesion to human aortic endothelial cells (HAEC) and on the production of reactive oxygen species (ROS). Plasma extracts of flavonoid metabolites were prepared after intragastric administration of pure compounds to rats. The plasma preparations contained sulfate or glucuronide conjugates or both and methylated forms. We measured adhesion of U937 monocytic cells to HAEC and the production of ROS in HAEC when cells were pretreated with either pure compounds or plasma extracts from control or treated rats. Adhesion assays were performed with HAEC stimulated with interleukin (IL)-1 beta or U937 cells activated with phorbol myristyl acetate; ROS were measured after challenging HAEC with IL-1 beta or hydrogen peroxide. Pretreatment of HAEC with (+)-catechin metabolites inhibited U937 cell adhesion to IL-1 beta-stimulated cells, whereas pretreatment with intact (+)-cat...Continue Reading

References

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·O R EtinginD P Hajjar
Feb 1, 1987·Biochemical Pharmacology·R J GryglewskiJ Swies
Apr 1, 1985·The Journal of Clinical Investigation·P E DiCorleto, C A de la Motte
Dec 1, 1995·The American Journal of Clinical Nutrition·P C HollmanM B Katan
Aug 1, 1994·The Journal of Clinical Investigation·R FaruqiP E DiCorleto
Aug 1, 1995·Bioscience, Biotechnology, and Biochemistry·T Unno, T Takeo
May 1, 1995·International Archives of Allergy and Immunology·E Middleton, S Anne
Jan 1, 1995·Biological & Pharmaceutical Bulletin·K OkushioY Hara
Jan 1, 1993·British Heart Journal·R M Faruqi, P E DiCorleto
Feb 26, 1993·Journal of Immunological Methods·A A VaporciyanP A Ward
Feb 24, 1996·BMJ : British Medical Journal·P KnektJ Maatela
Jan 1, 1996·Free Radical Biology & Medicine·C A Rice-EvansG Paganga
Feb 1, 1996·Biological & Pharmaceutical Bulletin·K OkushioY Hara
Jan 1, 1996·Free Radical Biology & Medicine·P C HollmanM B Katan
Sep 1, 1996·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·J PanésD N Granger
Dec 1, 1996·Bioscience, Biotechnology, and Biochemistry·T UnnoT Takeo
Jun 16, 1997·The Journal of Experimental Medicine·L M McEvoyE C Butcher
Jun 2, 1997·FEBS Letters·C ManachC Rémésy
Jun 18, 1998·The Journal of Nutrition·M SerafiniA Ferro-Luzzi
Jun 17, 1998·Free Radical Biology & Medicine·E L Da SilvaJ Terao
Feb 27, 1999·European Journal of Clinical Nutrition·M RichelleE A Offord
May 27, 1999·The Journal of Pharmacy and Pharmacology·D W BoultonT Walle
Aug 25, 1999·The Journal of Nutrition·J L DonovanA L Waterhouse
Sep 14, 1999·The American Journal of Physiology·H KobuchiL Packer
Jan 21, 2000·Free Radical Biology & Medicine·C ManachC Rémésy
Feb 12, 2000·Bioscience, Biotechnology, and Biochemistry·A NagaoH Kobayashi

❮ Previous
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Citations

Dec 24, 2003·Addiction Biology·E Sacanella, R Estruch
Apr 29, 2004·The American Journal of Clinical Nutrition·Claudine ManachLiliana Jiménez
Jun 24, 2004·The American Journal of Clinical Nutrition·Paul A KroonGary Williamson
Nov 1, 2006·International Journal of Clinical Practice·P KarM H Cummings
Jun 1, 2004·Nutrition Research Reviews·Karen A CooperDavid I Thurnham
Jul 25, 2009·The Journal of Nutrition·Mustali M Dohadwala, Joseph A Vita
Apr 5, 2011·Journal of Applied Microbiology·M KutscheraA Braune
Dec 29, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·P-Y ChaoC-M Yang
Jul 23, 2002·The Proceedings of the Nutrition Society·Mohsen Meydani
Jun 7, 2003·The American Journal of Clinical Nutrition·Karen J MurphyAndrew J Sinclair
Feb 11, 2003·Journal of Lipid Research·Maria Luisa BalestrieriLuigi Servillo
Feb 19, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ryan N FioriniKenneth D Chavin
Oct 2, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Nicoline JochmannVerena Stangl
Oct 20, 2010·The British Journal of Nutrition·Mary F-F ChongJulie A Lovegrove
Oct 28, 2009·Journal of Medicinal Food·Sarah L MorganAngela C Kendrach
Sep 16, 2009·The British Journal of Nutrition·Rosalind J MooreAnne M Minihane
Jan 1, 2009·Beilstein Journal of Organic Chemistry·Nian-Guang LiJin-Ao Duan
Jun 25, 2016·Beilstein Journal of Organic Chemistry·Lucian G BahrinLucian M Birsa
Dec 23, 2016·Archives of Physiology and Biochemistry·Tianyu ZhangQiang Dong
Jul 23, 2005·Free Radical Research·G WilliamsonJ Terao
Jan 22, 2008·The British Journal of Nutrition·Maria de Lourdes Mata-BilbaoRosa M Lamuela-Raventós
Aug 12, 2009·Journal of Cardiovascular Pharmacology·Yuji Naito, Toshikazu Yoshikawa
Apr 20, 2013·Journal of Cardiovascular Pharmacology·Ajaz AhmadKhalid M Alkharfy
Jun 24, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jian-Qing RuanRu Yan
Sep 27, 2013·Journal of Medicinal Food·Kuan-Hung LinPi-Yu Chao

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