PMID: 1197921Oct 1, 1975Paper

Effect of plasma protein binding on the anticoagulant action of warfarin in rats

Research Communications in Chemical Pathology and Pharmacology
A Yacobi, G Levy

Abstract

The relationships between the anticoagulant effect and the concentrations of free and total (sum of free and protein-bound) warfarin in plasma were determined in rats following intravenous administration of single doses of racemic warfarin or S(-)-warfarin. The concentration of total warfarin required to elicit a defined anticoagulant effect varied widely between animals while the concentration of free warfarin showed much less variation. This indicates that the anticoagulant effect of warfarin is a function of its free concentration in plasma.

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