Effect of plasticization on heparin release from biodegradable matrices

International Journal of Pharmaceutics
L P TanX T Wang

Abstract

Heparin-loaded polymer films of poly-L-lactide (PLLA) and poly-L-lactide-co-glycolide (PLLGA) as well as poly-DL-lactide-co-glycolide (PLGA) were produced. A plasticizer, PEG, was added to the polymers. It was found that the release profile in general consisted of a burst effect, a diffusion-controlled phase and a degradation-controlled phase. The plasticizer accelerated the onset of degradation in all cases, but its effect on the release profile differed significantly depending on the polymer. The plasticizer depressed the burst effect for PLLA, and accelerated the kinetics of the diffusion-controlled phase. For the PLLGA 80/20, however, the plasticizer had no significant effect on the release profile or kinetics. We explain these observations in terms of hydrophilicity and crystallinity effects.

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Citations

Feb 18, 2010·Journal of Materials Science. Materials in Medicine·N B TavakalyanA Mihranyan
Nov 5, 2013·International Journal of Pharmaceutics·Eva SnejdrovaMartin Drastik
Jan 1, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Raghu Raj Singh ThakurDavid S Jones
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May 18, 2012·Molecular Pharmaceutics·Filippo RossiGiuseppe Perale
Aug 8, 2021·Advanced Drug Delivery Reviews·Xiaoyi Wang, Diane J Burgess

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