Effect of platelet-derived growth factor-B on renal cell carcinoma growth and progression

Urologic Oncology
Wenling WangXin Yao

Abstract

Platelet-derived growth factor-B (PDGF-B) expression promotes the proliferation of mural cells surrounding the blood vessels during angiogenesis. The effect of PDGF-B involved in angiogenesis on tumor growth and progression in clear cell renal cell carcinoma (ccRCC) is unknown. We examined the expression of PDGF-B and its receptor PDGFR-β in 174 patients with ccRCC by microarray analysis. Cancer-specific survival was estimated using the Kaplan-Meier method. PDGF-B-transfected and mock-transfected ACHN cells were implanted into mice to induce tumor formation and tumor growth, respectively, and progression in mice models was assessed using immunohistochemistry and histomorphology. The role of PDGF-B during angiogenesis in vitro was evaluated by flow cytometry analysis, cell migration, and tube formation assay. High expression of PDGF-B was associated with significantly decreased risk of cancer-specific mortality (P ≤ 0.001). The data indicated significant inhibition of tumor growth (P ≤ 0.05) and a reduction in proliferating tumor cells (P = 0.019) in vivo. PDGF-B also inhibits tumor metastasis and invasion events in tumor-bearing mice models. In vitro studies revealed that the tube formation capability of vascular smooth muscle ...Continue Reading

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Citations

Jul 15, 2015·Cell Biochemistry and Function·Ammad Ahmad Farooqi, Zahid H Siddik
Jun 17, 2015·Medical Oncology·Le ChangAaron W James
Feb 1, 2018·Oncotarget·Jie YangJiaying Zhou
Sep 25, 2017·Journal of Internal Medicine·C-H HeldinB Westermark
May 20, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Pierre AgnassJohannes Crezee

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