Effect of PMA optical isomers and 4-MTA in PMMA-trained rats

Pharmacology, Biochemistry, and Behavior
M DukatR A Glennon

Abstract

1-(4-Methoxyphenyl)-2-aminopropane (PMA) and its sulfur analog, 1-(4-methylthiophenyl)-2-aminopropane (4-MTA), have been misrepresented as the controlled substance analog, N-methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA; "Ecstasy"). Because MDMA has been shown to produce both amphetamine-like and N-methyl-1-(4-methoxyphenyl)-2-aminopropane (PMMA)-like stimulus effects in rats, we examined S(+)PMA, R(-)PMA and 4-MTA in rats trained to discriminate either PMMA (1.25 mg/kg) or (+)amphetamine (1.0 mg/kg) from saline vehicle. The sulfur analog of PMMA (i.e., 4-MTMA) was also examined. The PMMA stimulus generalized to R(-)PMA (ED50=0.4 mg/kg), whereas S(+)PMA produced a maximum of 72% PMMA-appropriate responding. 4-MTA (ED50=0.3 mg/kg) also substituted for PMMA, but 4-MTMA produced a maximum of only 36% PMMA-appropriate responding. None of the four agents substituted for (+)amphetamine. Hence, like MDMA, R(-)PMA and 4-MTA are capable of producing PMMA stimulus effects in rats, but unlike MDMA, neither agent substituted for (+)amphetamine.

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Citations

Dec 13, 2006·Toxicology·Helena CarmoJan G Hengstler
Oct 29, 2005·Pharmacology, Biochemistry, and Behavior·Richard YoungRichard A Glennon
Jul 12, 2016·Forensic Science International : Synergy·Moonhee JangJihyun Kim
Sep 22, 2009·Forensic Science International : Synergy·Dariusz BłachutBogdan Szukalski
Oct 27, 2015·Neurotoxicity Research·Krystyna GołembiowskaAnna Górska
Nov 21, 2015·Therapeutic Drug Monitoring·Elli TyrkköRobert Kronstrand

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