Effect of Poli I:C in murine model of autoimmune thyroiditis

BioRxiv : the Preprint Server for Biology
Carolina Loreto Vera Sepulveda, MIguel Barria Maldonado

Abstract

Hashimoto's thyroiditis is one of the most common autoimmune diseases in humans and, similar to other autoimmune diseases, is multifactorial in nature. Moreover, the expression of TLRs has been implicated in the pathogenesis of autoimmune and inflammatory diseases, such as diabetes and insulinitis. The TLRs are a family of at least 10 receptors associated with innate immunity that are present in monocytes, macrophages, and dendritic cells, which recognize highly conserved patterns of the surface of microorganisms, such as LPS, peptidoglycan, and dsRNA and CpG sequences.

Related Concepts

Microorganism
Pathogenic Aspects
Patterns
Pathogenesis
Insulin/Insulin Receptor Signaling Pathway
RNA, Double-Stranded
Murine
Inflammatory Disorder
5'-Inosinic acid, 2'-deoxy-2'-fluoro-, homopolymer
Poly A

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