Effect of poliovirus on deoxyribonucleic acid synthesis in HeLa cells.

Journal of Bacteriology
W W AckermannS J Davies

Abstract

Ackermann, W. W. (University of Michigan, Ann Arbor), D. C. Cox, H. Kurtz, C. D. Powers, and S. J. Davies. Effect of poliovirus on deoxyribonucleic acid synthesis in HeLa cells. J. Bacteriol. 91:1943-1952. 1966.-Both poliovirus and arginine stimulated deoxyribonucleic acid (DNA) synthesis in cultures of HeLa cells which were preconditioned by incubation in a medium deficient in arginine. However, the number of cells producing DNA was unaffected. DNA synthesis in such preconditioned cells was 10 to 20% of the maximal value obtained with a full complement of amino acids. Inhibition of DNA synthesis was produced in these cultures either by increasing the multiplicity of exposure above 40 plaque-forming units of virus per cell or by increasing the concentration of the deficient amino acid at the time of virus addition. Inhibition of DNA synthesis resulted from a reduction in the fraction of cells producing DNA. The concentration of arginine required for viral inhibition of DNA synthesis is greater than that for viral multiplication.

References

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Citations

Jan 1, 1969·Archiv für die gesamte Virusforschung·F T Willems, W E Rawls
Dec 1, 1967·Journal of Cellular Physiology·P Aula, W W Nichols
Jun 1, 1971·Bacteriological Reviews·E Stanbridge
Oct 1, 1966·Journal of Bacteriology·W W Ackermann, D Wahl
Jun 1, 1969·Experimental Cell Research·J J Freed, S A Schatz

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