Effect of poly (ethylene glycol) molecular weight and microparticle size on oral insulin delivery from P(MAA-g-EG) microparticles

Drug Development and Industrial Pharmacy
Jennifer E López, Nicholas A Peppas

Abstract

Five years of successful work in our lab have shown that graft copolymer networks of poly(methacrylic acid-g-ethylene) [P(MAA-g-EG)], are very promising candidates for oral drug delivery. In an acidic environment, these copolymers form interpolymer complexes, protecting the active agent from the harsh environment of the gastrointestinal tract. At high pH, these complexes dissociate, causing the polymer to swell and release the drug. Films of P(MAA-g-EG) with a monomer ratio of 1:1 (MAA:EG) were prepared by free radical solution UV-polymerization, washed in order to remove the unreacted monomer, and crushed to form microparticles with different particle size distribution. Previous studies in our lab have focused on using polymer disks in their swelling studies. The swelling properties of polymer disks vs. crushed particles were investigated via equilibrium swelling experiments in this study. Another goal in this study is to compare different PEG chain length (MW-400 and MW-1000) and different particle size (150-212 microns, 90-150 microns and 25-90 microns) in their loading and release behavior. After 6 hours of exposing the polymer with the insulin solution we achieved approximately 90% of insulin loading.

References

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Jun 24, 2004·Journal of Biomaterials Science. Polymer Edition·Jennifer E López, Nicholas A Peppas

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Citations

Nov 16, 2006·Bioconjugate Chemistry·Nikhil J KavimandanNicholas A Peppas
Jul 27, 2012·Therapeutic Delivery·Colin Thompson, Chidinma Ibie
Sep 21, 2007·Advanced Drug Delivery Reviews·El-Sayed KhafagyKozo Takayama
Feb 12, 2008·International Journal of Pharmaceutics·Nikhil J Kavimandan, Nicholas A Peppas
Apr 1, 2005·Journal of Microencapsulation
Jan 3, 2013·Journal of Biomedical Materials Research. Part a·Cody A SchoenerNicholas A Peppas
Jan 17, 2012·Industrial & Engineering Chemistry Research·Cody A SchoenerNicholas A Peppas
May 3, 2016·Materials Science & Engineering. R, Reports : a Review Journal·Michael C KoettingNicholas A Peppas

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