Effect of poly ethylene glycol on the mechanical and thermal properties of bioactive poly(ε-caprolactone) melt extrudates for pharmaceutical applications

International Journal of Pharmaceutics
P DouglasG M Walker

Abstract

This paper investigates the effects of polyethylene glycol (PEG), on the mechanical and thermal properties of nalidixic acid/poly ε-caprolactone (NA)/PCL blends prepared by hot melt extrusion. The blends were characterized by tensile and flexural analysis, dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis and X-ray diffraction. Results show that loading PEG in the PCL had a detrimental effect on the tensile strength and toughness of the blends, reducing them by 20-40%. The partial miscibility of the PCL-PEG system, causes an increase in Tg. While increases in the crystallinity is attributed to the plasticisation effect of PEG and the nucleation effect of NA. The average crystal size increased by 8% upon PEG addition. Experimental data indicated that the addition of NA caused loss of the tensile strength and toughness of PCL. Thermal analysis of the PCL showed that on addition of the thermally unstable NA, thermal degradation occurred early and was autocatalytic. However, the NA did benefit from the heat shielding provided by the PCL matrix resulting in more thermally stable NA particles.

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Citations

Apr 13, 2018·Materials·Tamer M TamerLadislav Šoltés
Aug 5, 2017·Materials·Tobias ZehnderAldo R Boccaccini
Nov 8, 2020·Journal of Materials Science. Materials in Medicine·Mei-Chen LinYueh-Sheng Chen
Jan 29, 2020·International Journal of Biological Macromolecules·Wanmei LinJie Pang
Mar 2, 2021·International Journal of Biological Macromolecules·Murilo Santos PachecoMariana Agostini de Moraes
Mar 18, 2021·International Journal of Biological Macromolecules·Mohammad ShahrousvandMohsen Shahrousvand
Mar 27, 2021·International Journal of Biological Macromolecules·Diksha Verma, Sunil K Sharma
May 22, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Samuel SolomonAhmad B Albadarin
Aug 16, 2021·International Journal of Pharmaceutics·Sarah A StewartEneko Larrañeta

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