Effect of polyamines on perfused rat heart contractility

Pharmacological Research Communications
C BazzaniA Bertolini


The influence of polyamines (putrescine, spermidine and spermine) on heart contractility was studied using perfused rat ventricle strips (2 X 10 mm), electrically driven at 1 Hz. Putrescine (100 microM) caused a negative inotropic effect gradually increasing in intensity, whereas spermidine and spermine (10 and 100 microM) caused a sharp, positive inotropic effect, followed by a rapid and more marked fall. The possibility that these effects of polyamines on heart contractility may be due to their role in Ca++ fluxes and mobilization, and in membrane functions, is discussed.


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Oct 13, 1987·European Journal of Pharmacology·V KecskemetiL Selmeci
Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·P A Ferchmin, V A Eterović
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S P HarrisR L Moss

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