Effect of polycan, a β-glucan originating from Aureobasidium, on a high-fat diet-induced hyperlipemic hamster model

Experimental and Therapeutic Medicine
Mee-Kyoung LimJoo Wan Kim

Abstract

The aim of the present study was to analyze the effect of polycan, a β-glucan originating from Aureobasidium, on high-fat diet (HFD)-induced hyperlipemia and hepatic damage. A total of 30 hamsters were divided into 6 groups based on their body weight following acclimatization: control, sham, simvastatin (SIMVA) and 3 Polycan groups. In the polycan groups, Polycan, at three concentrations (31.25, 62.5 and 125 mg/kg), was administered orally once a day for 56 days, in addition to the HFD. On the day of sacrifice, changes in the body weight, food consumption, liver weight and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride and total cholesterol (T-CHOL) were observed, as well as changes to the liver and aorta (thoracic and abdominal) histopathology and histomorphometry. The results from the polycan groups were compared with a SIMVA 10 mg/kg oral treatment group, in addition to the sham and vehicle control groups. After the HFD-induced hyperlipidemic hamsters were administered Polycan, there was no significant change in their body weight and food consumption when compared with the hamsters in the vehicle control group. Howe...Continue Reading

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Citations

Sep 6, 2017·International Journal of Molecular Sciences·Khawaja Muhammad Imran Bashir, Jae-Suk Choi
Apr 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vaclav VetvickaJosef Richter
Jun 5, 2019·The Journal of Nutrition·Sharon H KimMohsen Meydani
Feb 3, 2018·International Journal of Molecular Medicine·Petr SimaVaclav Vetvicka
May 4, 2017·Lipids in Health and Disease·Meng-Jie ZhaoHong Xiao
Apr 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tatiana A KorolenkoVaclav Vetvicka

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Methods Mentioned

BETA
light microscopy

Software Mentioned

analySIS
SIMVA
SPSS

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