PMID: 107617Dec 1, 1978

Effect of polychlorinated biphenyls on drug metabolism in Japanese quail and its progeny

Toxicology
J L RivièreG Grolleau

Abstract

PCB (DP5, 1 and 5 mg/female/day, orally for 40 days) induce microsomal hepatic enzymes (cytochrome P-450, aniline hydroxylase, aldrin epoxidase, p-nitroanisole demethylase, p-nitrophenol: UDPGA-transferase) in adult female Japanese quail. Toxicity of dinitro-o-cresol (DNOC) is reduced in treated animals. High hepatic activity occurs in young quails issued from treated females, but closely related to residue levels, normal enzyme activities are reestablished within 1 month.

References

Mar 1, 1978·Toxicology and Applied Pharmacology·P J Bunyan, J M Page
Apr 1, 1975·Bulletin of Environmental Contamination and Toxicology·F IversonG V Hatina
May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·A P AlvaresA Kappas
Dec 1, 1973·Toxicology and Applied Pharmacology·T S Chien, K P DuBois
Apr 1, 1974·Toxicology and Applied Pharmacology·G J JohnstoneO Hutzinger
Mar 1, 1974·Bulletin of Environmental Contamination and Toxicology·C L Litterst, E J Van Loon
Nov 1, 1974·Chemico-biological Interactions·D J Ecobichon, A M Comeau
Sep 1, 1972·Toxicology and Applied Pharmacology·C L LitterstE J Van Loon
Dec 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·C L Litterst, E J Van Loon
Dec 14, 1968·Nature·R W RisebroughM N Kirven

Citations

Nov 1, 1981·Archives of Environmental Contamination and Toxicology·A Biessmann
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J L RivièreJ Bach
Feb 1, 1982·Acta Pharmacologica Et Toxicologica·B BrunströmU Lundkvist

Related Concepts

Japanese Quail
Cytochrome P-450 Oxygenase
Dinitrocresols
Pharmaceutical Preparations
Mixed Function Oxygenases
Liver
Polychlorinated Biphenyls
UDP-Glucuronic Acid 3-O-beta-D-Galactosyl-D-Galactose Glucuronosyltransferase

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