PMID: 6538499Mar 1, 1984Paper

Effect of polyethylene glycol 400 on adriamycin toxicity in mice

European Journal of Cancer & Clinical Oncology
F B KlugmannL Baldini

Abstract

The effect of a widely used organic solvent, polyethylene glycol 400 (PEG 400), on the toxic action of an acute or chronic treatment with adriamycin (ADR) was evaluated in mice. PEG 400 impressively decreased both acute high-dose and chronic low-dose-ADR-associated lethality. Light microscopic analysis showed a significant protection against ADR-induced cardiac morphological alterations. Such treatment did not diminish the ADR antitumor activity in L1210 leukemia and in Ehrlich ascites tumor.

References

Dec 18, 1978·Life Sciences·J S Lockard, R H Levy
May 1, 1977·Journal of Molecular and Cellular Cardiology·M W SeraydarianM F Goodman
Jun 20, 1977·Biochemical and Biophysical Research Communications·W G BesslerJ H Peters
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Jun 1, 1982·Cancer Treatment Reviews·D V UnverferthS P Balcerzak
Sep 15, 1982·Toxicology and Applied Pharmacology·D A HeroldR F Edlich

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Citations

Feb 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S J HermanskyH W Leung
Feb 1, 1986·Pharmacological Research Communications·F Bartoli KlugmannL Baldini
Sep 15, 1990·International Journal of Cancer. Journal International Du Cancer·M WakselmanC Chany
Dec 1, 1993·The Journal of Pharmacy and Pharmacology·P HoffmannK P Döpfer

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