PMID: 8955851Dec 1, 1996Paper

Effect of polyionic compounds on the adsorption of polyoma virus

Antiviral Research
Y W Yang, J C Yang

Abstract

The inhibitory effect of polyionic compounds, including dextran sulfates and poly-L-lysines of various molecular weight, on the cytopathogenicity of polyoma virus was studied. Poly-L-lysines were found to be more potent inhibitors of polyoma virus than dextran sulfates in UC1B cells. The 50% effective concentrations (EC50) were found to be inversely related to the molecular weight of the polymers. The higher the molecular weight of poly-L-lysine, the more effective was the polymer in inhibiting virus-induced cytopathogenicity. Incubation of the cells with poly-L-lysines was found to increase the zeta potential of the cells, whereas no significant change of the electrokinetic behavior was observed for dextran sulfate-treated cells, indicating that poly-L-lysines were adsorbed to the cells and prevented virus adsorption through steric hindrance effect. Studies using 3H-labeled virions confirmed that poly-L-lysines inhibit virus adsorption to the host cells. The results obtained from this study indicated that poly-L-lysines bind preferentially to UC1B cells through electrostatic interactions, whereas dextran sulfates are not effective inhibitors of polyoma virus.

References

Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M BabaE De Clercq
Jun 1, 1988·The Journal of General Virology·N LangelandL Haarr
Jul 1, 1985·Antimicrobial Agents and Chemotherapy·E De Clercq
May 1, 1980·The Journal of Infectious Diseases·E De ClercqD Shugar

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Citations

Mar 6, 2013·Journal of Pharmaceutical Sciences·Shigeo TakemuraKazutaka Higaki

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