PMID: 15376639Sep 21, 2004Paper

Effect of polymer surface activity on cavitation nuclei stability against dissolution

The Journal of the Acoustical Society of America
Tyrone M PorterAllan S Hoffman

Abstract

The persistence of acoustic cavitation in a pulsed wave ultrasound regime depends upon the ability of cavitation nuclei, i.e., bubbles, to survive the off time between pulses. Due to the dependence of bubble dissolution on surface tension, surface-active agents may affect the stability of bubbles against dissolution. In this study, measurements of bubble dissolution rates in solutions of the surface-active polymer poly(propyl acrylic acid) (PPAA) were conducted to test this premise. The surface activity of PPAA varies with solution pH and concentration of dissolved polymer molecules. The surface tension of PPAA solutions (55-72 dynes/cm) that associated with the polymer surface activity was measured using the Wilhelmy plate technique. Samples of these polymer solutions then were exposed to 1.1 MHz high intensity focused ultrasound, and the dissolution of bubbles created by inertial cavitation was monitored using an active cavitation detection scheme. Analysis of the pulse echo data demonstrated that bubble dissolution time was inversely proportional to the surface tension of the solution. Finally, comparison of the experimental results with dissolution times computed from the Epstein-Plesset equation suggests that the radii of ...Continue Reading

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Citations

Nov 18, 2011·The Journal of the Acoustical Society of America·Douglas L Miller, Chunyan Dou
Mar 17, 2015·Drug Development and Industrial Pharmacy·Srinivasan ShanmugamJong Soo Woo
Feb 28, 2006·Biophysical Journal·Mamadou Diop, Rod Taylor
Mar 27, 2007·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Wen LuoGuangbin He
Jul 21, 2006·The Journal of Physical Chemistry. B·Judy LeeMuthupandian Ashokkumar
Sep 15, 2006·The Journal of Physical Chemistry. B·Limei YangLinda K Weavers

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