Effect of polysaccharides from Opuntia ficus-indica (L.) cladodes on the healing of dermal wounds in the rat

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
D TrombettaF Bonina

Abstract

In traditional medicine extracts of polysaccharide-containing plants are widely employed for the treatment of skin and epithelium wounds and of mucous membrane irritation. The extracts of Opuntia ficus-indica cladodes are used in folk medicine for their antiulcer and wound-healing activities. The present study describes the wound-healing potential of two lyophilized polysaccharide extracts obtained from O. ficus-indica (L.) cladodes applied on large full-thickness wounds in the rat. When topically applied for 6 days, polysaccharides with a molecular weight (MW)>10(4)Da from O. ficus-indica cladodes induce a beneficial effect on cutaneous repair in this experimental model; in particular the topical application of O. ficus-indica extracts on skin lesions accelerates the reepithelization and remodelling phases, also by affecting cell-matrix interactions and by modulating laminin deposition. Furthermore, the wound-healing effect is more marked for polysaccharides with a MW ranging 10(4)-10(6)Da than for those with MW>10(6)Da, leading us to suppose that the fine structure of these polysaccharides and thus their particular hygroscopic, rheologic and viscoelastic properties may be essential for the wound-healing promoter activity obse...Continue Reading

References

Sep 1, 1994·Biological & Pharmaceutical Bulletin·M TomodaK Hirabayashi
Sep 1, 1996·The International Journal of Biochemistry & Cell Biology·K M Malinda, H K Kleinman
Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·S E MutsaersG J Laurent
Mar 21, 1998·Journal of Ethnopharmacology·P ChithraG Chandrakasan
May 7, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·W Y Chen, G Abatangelo
Jan 12, 2000·Burns : Journal of the International Society for Burn Injuries·V MoulinL Germain
Jun 23, 2000·The Journal of Pharmacy and Pharmacology·L RaimondiR Pirisino
Jan 4, 2001·Journal of Dermatological Science·T NishiyamaR E Burgeson
Feb 27, 2001·Fitoterapia·E H Park, M J Chun
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·F M Strickland
Feb 15, 2002·Archives of Dermatology·Monica K Bedi, Philip D Shenefelt

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Citations

Jan 1, 2009·Journal of Dietary Supplements·Francis Brinker
Feb 9, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L Y ZhaoF H Zeng
Nov 10, 2015·Journal of Ethnopharmacology·Christian AgyareTheresa Appiah
Aug 27, 2015·International Journal of Biological Macromolecules·Imene AmmarMonia Ennouri
Jul 4, 2008·International Immunopharmacology·Igor A SchepetkinMark T Quinn
Jun 10, 2015·International Journal of Biological Macromolecules·Mohamed Aymen ChaouchHatem Majdoub
Jul 19, 2011·International Journal of Biological Macromolecules·Yang ChenLianjun Guo
Sep 22, 2007·Journal of Ethnopharmacology·B KumarP Pushpangadan
Aug 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luis R Camelo CaballeroMaría Carolina Otálora
Mar 12, 2011·International Journal of Food Sciences and Nutrition·Mehmet Musa Özcan, Fahad Y Al Juhaimi
Jan 24, 2017·Molecular Medicine Reports·Kavitha VijayaraghavanMohammed Ali Seyed
Dec 1, 2019·International Journal of Biological Macromolecules·Zohra GhlissiZouheir Sahnoun
Sep 28, 2018·International Journal of Biological Macromolecules·Mohamed Aymen ChaouchHatem Majdoub
Aug 23, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Omid YazarluMaede Hasanpour
Feb 4, 2022·Archives of Insect Biochemistry and Physiology·Isabella C V NovaEmmanuel V Pontual

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