PMID: 3214457Jul 1, 1988Paper

Effect of polyunsaturated fatty acids of the n-3 and n-6 series on lipid composition and eicosanoid synthesis of platelets and aorta and on immunological induction of atherosclerosis in rabbits

Atherosclerosis
C Bolton-SmithK Hillier

Abstract

The effect of dietary fish oil (rich in n-3 polyunsaturated fatty acids (PUFA], corn oil (rich in n-6 PUFA) and coconut oil (low in n-3 and n-6 PUFA) on the induction of atherosclerosis by serum sickness in rabbits was investigated over a 12-month period. Dietary fish oil led to a significant increase in the level of eicosapentaenoic acid (EPA) in all platelet phospholipid fractions and to a significant reduction in the level of platelet phosphatidylethanolamine arachidonic acid (AA). In aortic total phospholipids, rabbits given fish oil showed a significant reduction in AA and a significant increase in EPA. Rabbits given fish oil showed significantly lower collagen-induced platelet thromboxane A2 release and aortic production of 6-keto-PGF1 alpha. Serum total immune complex levels and anti-horse serum IgG levels were not influenced by diet. There was a significant reduction in total aortic atherosclerosis in fish oil-fed animals compared with coconut oil fed animals.

References

Nov 1, 1979·Prostaglandins and Medicine·K L BlackW E Lands
Nov 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Satoh
Oct 2, 1986·The New England Journal of Medicine·B H WeinerM H Johnson

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Citations

Apr 1, 1994·Cardiovascular Drugs and Therapy·L M SassenP D Verdouw
Jan 1, 1990·Journal of the American College of Cardiology·B Q ZhuW W Parmley
Jan 1, 1992·Journal of the American College of Cardiology·D H Israel, R Gorlin
Jan 1, 1991·Experimental Pathology·J GmińskiP Sułkowski
Nov 1, 1989·The British Journal of Nutrition·J KearneyM J Gibney
Dec 18, 1990·The American Journal of Cardiology·W W Parmley
Oct 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C M SmutsA J Benadé
Mar 27, 2018·Annual Review of Nutrition·Michael J Gibney
Feb 9, 2012·Alcoholism, Clinical and Experimental Research·John C CrabbePamela Metten
Jul 26, 2017·Journal of Cardiovascular and Thoracic Research·Mirhamid Paytakhti OskoueiMohammad Nouri

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