Effect of pore size and morphology of activated charcoal prepared from midribs of Elaeis guineensis on adsorption of poisons using metronidazole and Escherichia coli O157:H7 as a case study

Journal of Microscopy and Ultrastructure
Margaret O IlomuanyaCecilia I Igwilo

Abstract

Agricultural waste obtained from Elaeis guineensis mid ribs can provide a veritable source of materials which can be used as precursor materials for the production of pharmaceutical grade activated charcoal. The pore size and surface morphology of activated charcoal defines the types of molecules that could be adsorbed unto it, as surface morphology plays a significant role in determining the surface availability and areas of adsorption. The activated charcoal samples prepared from Elaeis guineensis via either physical or chemical activation was characterized via surface area using the BET method and subsequently pore structure and size analyzed by scanning electron microscopy (SEM). Physically activated Elaeis guineensis fronds activated with nitrogen gas had wide spread microporosity with micropore volume of 0.232 cc/g compared to the chemically activated with 1M and 3M phosphoric acid respectively. The commercial activated charcoal/metronidazole combination in the in vitro-pharmacodynamic model reflected no re-growth after 4 hours, however for charcoal formulated from Elaeis guineensis via chemical activation with 3M phosphoric acid and metronidazole no regrowth was seen at the second hour and this was maintained throughout ...Continue Reading

References

May 1, 1980·The Journal of Antimicrobial Chemotherapy·H R InghamJ B Selkon
Nov 1, 1993·Antimicrobial Agents and Chemotherapy·R A ZabinskiJ C Rotschafer
Apr 20, 2001·The Journal of Veterinary Medical Science·K NakaH Kodama
Sep 25, 2008·Nature Clinical Practice. Gastroenterology & Hepatology·Udayakumar Navaneethan, Ralph A Giannella
Sep 26, 2015·Rapid Communications in Mass Spectrometry : RCM·Margaret IlomuanyaCecilia Igwilo

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Methods Mentioned

BETA
scanning electron microscopy

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