Aug 23, 1976

Effect of portacaval anastomosis on the activities of hepatic enzymes related to cholesterol and bile acid metabolism in rats

Biochimica Et Biophysica Acta
S BalasubramaniamN B Myant


1. The effect of a portacaval anastomosis on the activities of hepatic enzymes related to cholesterol metabolism was investigated in rats. 2. Portacaval anastomosis led to a fall in body weight and liver weight/body weight ratio, and to a rise in the activities of hydroxymethylglutaryl-CoA reductase and cholesterol 7alpha-hydroxylase per g of liver. The net effect was to maintain a normal activity of both enzymes per 100 g of rat. Diurnal rhythm in the activities of both enzymes was maintained after portacaval anastomosis. 3. The rate of excretion of total bile acids, per 100 g of rat, in bile fistula rats was not significantly decreased by portacaval anastomosis.

Mentioned in this Paper

Anatomical Anastomosis
Cholesterol Metabolic Process
Enzymes, antithrombotic
HMGCR gene
Tyrosine Aminotransferase
Weighing Patient
Hydroxymethylglutaryl-CoA reductase

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