Effect of portal hypertension on in vivo bile acid-mediated small intestinal mucosal injury in the rat

Digestive Diseases and Sciences
G JonasT Morgan

Abstract

This study's purpose was to determine whether portal hypertension adversely affects small intestinal mucosal injury. Portal hypertension was produced in male Sprague-Dawley rats by two-stage ligation of the portal vein. Sham-operated rats were used as controls. Two weeks later, intestinal injury was produced by in vivo perfusion with 5 mM chenodeoxycholic acid for 30 min. Intestinal injury was assessed by quantitative morphometry and by measuring intestinal water and mannitol absorption. Portal hypertension resulted in more injury in the distal perfused intestine as manifested by increased villus tip denudation [portal hypertensive 52.5 +/- 9.6 (SEM) vs controls 28.1 +/- 5.7 microns, P = 0.05). Additionally there was a significant decrease in the unperfused duodenal villus height in portal hypertensive rats (portal hypertensive 755 +/- 22 vs controls 848 +/- 28 microns, P less than 0.02). Portal hypertension had no significant effect on the increase in mannitol absorption or water secretion caused by chenodeoxycholic acid perfusion. This study suggests that portal hypertension alters small intestinal mucosa and increases susceptibility to injury.

References

Nov 1, 1978·The American Journal of the Medical Sciences·H G WilcoxS Schenker
Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S TarnawskiH Gergely
Nov 1, 1987·Gastroenterology·I J Sarfeh, A Tarnawski
Nov 1, 1974·The American Journal of Digestive Diseases·J R MalageladaW G Linscheer
Apr 1, 1970·The American Journal of Clinical Nutrition·C M LeevyH Baker
Dec 1, 1965·The Journal of Clinical Investigation·J S FordtranJ Kinney
Jun 1, 1967·Archives of Internal Medicine·D C SunJ K Chen
May 10, 1954·Annals of the New York Academy of Sciences·G J GABUZDA, C S DAVIDSON
Jul 1, 1960·The American Journal of Digestive Diseases·G ASTALDI, E STROSSELLI

❮ Previous
Next ❯

Citations

Dec 19, 2012·Digestive Diseases and Sciences·Taiki AoyamaKazuaki Chayama
Feb 3, 2011·Hepatology International·Gurbakhshish Singh SidhuKartar Singh
Jan 20, 2004·Medical Hypotheses·M A AllerJ Arias
Oct 13, 2017·Journal of Gastroenterology and Hepatology·Ichiro OtaniKazuaki Chayama
Feb 1, 1991·Alimentary Pharmacology & Therapeutics·G M JonasK Chung
Dec 6, 2018·International Journal of Hepatology·Yasir Al-AzzawiDavid Cave

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.