PMID: 3762136Sep 1, 1986Paper

Effect of portal vein occlusion on liver blood flow in normal and cirrhotic dogs

The Journal of Surgical Research
S S Hanna, Y Maheshwari

Abstract

The purpose of this study was to demonstrate that galactose clearance (GC) can measure acute changes in liver blood flow (LBF) in normal and cirrhotic dogs. Ten dogs were studied. GC was measured preop. At laparotomy, GC, hepatic artery (HA) flow, portal vein (PV) flow, and cardiac output (CO) were measured at baseline, 50% portal vein occlusion (PVO), and portal vein release. HA and PV flows were measured using a flow probe (FP). Common bile duct ligation was then performed to cause cirrhosis and all measurements were repeated in 7 weeks. Statistical analyses showed that on PVO in both normal dogs (n = 10) and cirrhotic dogs (n = 5) the GC, HA flow, and CO were significantly different from their baseline values. In both groups PVO caused HA flow to increase, thus keeping FP-LBF unchanged while GC-LBF was significantly reduced compared to baseline. The possible explanations for this are discussed in the text. PVO also caused a significant reduction in CO due to splanchnic pooling in both normal and cirrhotic dogs. In both groups PVO results in an increased percentage of CO going to FP-LBF, while the percentage of CO going to GC-LBF remains unchanged. We conclude that GC can measure acute changes in LBF caused by a 50% PVO in bo...Continue Reading

References

Dec 30, 1976·The New England Journal of Medicine·S Sherlock
Oct 1, 1968·The Journal of Surgical Research·A M GeumeiA Aboul-Enein
Nov 19, 1965·Science·J L Ternberg, H R Butcher
Nov 1, 1983·Pflügers Archiv : European journal of physiology·R T Mathie, L H Blumgart
Aug 1, 1982·European Journal of Clinical Investigation·L Blanchet, D Lebrec

❮ Previous
Next ❯

Citations

Mar 1, 1990·Digestive Diseases and Sciences·C Piasecki, A M Seifalian
May 22, 1998·Journal of Veterinary Internal Medicine·J DeMarcoB A Valentine
Feb 12, 2010·Kidney International·Juan A Oliver, Elizabeth C Verna
Jun 24, 2009·The Veterinary Journal·S SilvaE J Hall
Dec 31, 1997·The Journal of Veterinary Medical Science·K YamazoeT Kudo
May 1, 1991·Biopharmaceutics & Drug Disposition·R SallieR Williams
May 26, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Taku AokiMasatoshi Makuuchi
Aug 1, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·S RichterB Vollmar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.