Effect of post-ruminal guanidinoacetic acid supplementation on creatine synthesis and plasma homocysteine concentrations in cattle

Journal of Animal Science
Mehrnaz ArdalanEvan C Titgemeyer

Abstract

Creatine stores high-energy phosphate bonds in muscle, which is critical for muscle activity. In animals, creatine is synthesized in the liver from guanidinoacetic acid (GAA) with methylation by S-adenosylmethionine. Because methyl groups are used for the conversion of GAA to creatine, methyl group deficiency may occur as a result of GAA supplementation. With this study, the metabolic responses of cattle to post-ruminal supplementation of GAA were evaluated with and without methionine (Met) supplementation as a source of methyl groups. Six ruminally cannulated Holstein heifers (520 kg) were used in a split-plot design with treatments arranged as a 2 × 5 factorial. The main plot treatments were 0 or 12 g/d of l-Met arranged in a completely randomized design; three heifers received each main plot treatment throughout the entire experiment. Subplot treatments were 0, 10, 20, 30, and 40 g/d of GAA, with GAA treatments provided in sequence from lowest to highest over five 6-d periods. Treatments were infused continuously to the abomasum. Heifers were limit-fed twice daily a diet consisting of (dry matter basis) 5.3 kg/d rolled corn, 3.6 kg/d alfalfa hay, and 50 g/d trace-mineralized salt. Plasma Met increased (P < 0.01) when Met was...Continue Reading

References

Oct 1, 1996·Journal of Animal Science·C G CampbellG St-Jean
Apr 1, 1997·Journal of Animal Science·C G CampbellR T Brandt
Mar 18, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·K J Shingfield, N W Offer
Jul 14, 2000·Physiological Reviews·M Wyss, R Kaddurah-Daouk
Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·L M SteadJ T Brosnan
Oct 7, 2004·The Journal of Nutrition·Margaret E Brosnan, John T Brosnan
Feb 9, 2005·The American Journal of Clinical Nutrition·Kerry-Ann da CostaSteven H Zeisel
May 17, 2006·The Journal of Nutrition·John T Brosnan, Margaret E Brosnan
Jan 24, 2007·The Journal of Nutrition·Kelly T Williams, Kevin L Schalinske
Apr 14, 2007·Annual Review of Nutrition·John T Brosnan, Margaret E Brosnan
Oct 12, 2007·American Journal of Physiology. Renal Physiology·Erica E EdisonJohn T Brosnan
Jul 8, 2008·Bioscience, Biotechnology, and Biochemistry·Minoru SetoueKimio Sugiyama
Jan 22, 2010·BioFactors·Kelly T Williams, Kevin L Schalinske
Feb 18, 2010·Journal of Inherited Metabolic Disease·Martha H Stipanuk, Iori Ueki
Mar 23, 2010·Molecular Genetics and Metabolism·John T Brosnan, Margaret E Brosnan
Sep 29, 2012·Biochimica Et Biophysica Acta·Oksana TehlivetsWalter Keller
Jan 19, 2013·International Journal of Medical Sciences·Sergej M OstojicMilos Obrenovic
Oct 5, 2013·Molecular Genetics and Metabolism·Marie Joncquel-Chevalier CurtJoseph Vamecq
Feb 19, 2014·European Journal of Nutrition·Sergej M OstojicJay R Hoffman
Jan 28, 2015·Nutrition Research·Sergej M Ostojic, Aleksandra Vojvodic-Ostojic
Sep 29, 2015·European Journal of Nutrition·Sergej M Ostojic
Apr 12, 2016·Journal of Animal Science·E D BatistaE C Titgemeyer

❮ Previous
Next ❯

Citations

Aug 28, 2020·Journal of Animal Science·Hannah F SpeerEvan C Titgemeyer
Jun 25, 2021·Journal of Animal Science·Mehrnaz ArdalanEvan C Titgemeyer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.