Effect of postmenopausal hormone therapy on lipoprotein(a) concentration. PEPI Investigators. Postmenopausal Estrogen/Progestin Interventions

Circulation
M EspelandT L Bush

Abstract

Postmenopausal hormone therapy has been reported to decrease levels of lipoprotein (Lp)(a) in cross-sectional studies and small or short-term longitudinal studies. We report findings from a large, prospective, placebo-controlled clinical trial that allows a broad characterization of these effects for four regimens of hormone therapy. The Postmenopausal Estrogen/Progestin Interventions study was a 3-year, placebo-controlled, randomized clinical trial to assess the effect of hormone regimens on cardiovascular disease risk factors in postmenopausal women 45 to 65 years of age. The active regimens were conjugated equine estrogens therapy at 0.625 mg daily, alone or in combination with each of three regimens of progestational agents: medroxyprogesterone acetate (MPA) at 2.5 mg daily (ie, continuous MPA), MPA at 10 mg days 1 to 12 (ie, cyclical MPA), and micronized progesterone at 200 mg days 1 to 12. Plasma levels of Lp(a) were measured at baseline (n = 366), 12 months (n = 354), and 36 months (n = 342). Assignment to hormone therapy resulted in a 17% to 23% average drop in Lp(a) concentrations relative to placebo (P<.0001), which was maintained across 3 years of follow-up. No significant differences were observed among the four act...Continue Reading

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References

Dec 15, 1992·Annals of Internal Medicine·D GradyS R Cummings
Nov 19, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M J van der MoorenR Rolland
Jan 1, 1986·Methods in Enzymology·P S Bachorik, J J Albers
Oct 1, 1995·Baillière's Clinical Endocrinology and Metabolism·P N Durrington

❮ Previous
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Citations

Oct 23, 2015·International Journal of Endocrinology·Minqian Shen, Haifei Shi
Nov 11, 1999·Current Opinion in Lipidology·J E Rossouw
Feb 26, 2000·Journal of Internal Medicine·S DjurovicM Abdelonoor
Jul 2, 2002·The American Journal of Geriatric Cardiology·Marian C Limacher
Aug 7, 2002·Current Atherosclerosis Reports·Jennifer E Ho, Lori Mosca
Sep 24, 2004·European Journal of Clinical Investigation·J R GreenfieldL V Campbell
Sep 1, 2001·The Physician and Sportsmedicine·E A Dowling
Sep 3, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Maryam DarabiAhmad Movahedian
Mar 5, 2015·Current Atherosclerosis Reports·Lillian C ManDanielle Duffy
Sep 19, 2015·The Journal of Endocrinology·Sarit Ben-ShmuelRan Rostoker
May 17, 2017·Menopause : the Journal of the North American Menopause Society·David F ArcherSusannah Cort
Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J S ParkH S Chi
Mar 11, 2003·Menopause : the Journal of the North American Menopause Society·UNKNOWN North American Menopause Society
Sep 13, 2003·The Journal of Cardiovascular Nursing·S Penckofer, D Schwertz
Jun 6, 2002·Diabetes, Obesity & Metabolism·R W C Pang, K S L Lam
Aug 11, 2006·Climacteric : the Journal of the International Menopause Society·R D Arias
Mar 11, 2015·The Cochrane Database of Systematic Reviews·Henry M P BoardmanBeatrice Knight
Sep 12, 2015·Journal of Menopausal Medicine·Jee-Yeon LeeByung-Koo Yoon
Aug 21, 2014·The Journal of Pharmacology and Experimental Therapeutics·Fengjuan LiLai K Leung
Nov 22, 2017·Lipids in Health and Disease·Yifan Jiang, Weijie Tian
Apr 7, 1999·Current Opinion in Cardiology·L J SemanE J Schaefer
Oct 26, 1999·Journal of Endocrinological Investigation·N K Wenger, D Grady
Nov 25, 2003·Menopause : the Journal of the North American Menopause Society·Majoie HemelaarPeter Kenemans
Sep 30, 2003·Diabetes Care·Katherine M NewtonWilliam Barlow
Mar 16, 2005·Treatments in Endocrinology·Aun-Yeong Chong, Gregory Y H Lip
Sep 28, 2001·Current Opinion in Cardiology·M T Scheuner
Jun 1, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Susan E BromleyRichard D T Farmer
May 15, 2013·Future Cardiology·Christine L Chiu, Joanne M Lind
Sep 13, 2019·Journal of Lipid Research·Matthew T MeffordRobert S Rosenson
Jan 15, 2002·The Australian & New Zealand Journal of Obstetrics & Gynaecology·I S SerinM Tayyar
Sep 10, 2002·Menopause : the Journal of the North American Menopause Society·Göran SamsioeSören Larsen
Aug 7, 2001·Current Atherosclerosis Reports·P S KhuranaJ Hsia
Mar 30, 1999·Current Opinion in Lipidology·L Puckey, B Knight
Feb 9, 2002·Preventive Cardiology·N Goldberg
Jun 10, 2000·Current Opinion in Nephrology and Hypertension·H Mattix, A K Singh
Jun 1, 2001·Acta Clinica Belgica·B Velkeniers

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