Effect of postoperative diclofenac on anastomotic healing, skin wounds and subcutaneous collagen accumulation: a randomized, blinded, placebo-controlled, experimental study

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
Mads KleinJacob Rosenberg

Abstract

Retrospective studies have drawn attention to possible detrimental effects of non-steroidal anti-inflammatory drugs (NSAIDs) on the anastomotic leakage rate after colorectal resection. In this study, we examined the effects of the NSAID diclofenac on the breaking strength of an experimental colonic anastomosis and a skin incision as well as subcutaneous collagen accumulation. This was a randomized, blinded, placebo-controlled experimental study in 60 male Wistar rats treated with diclofenac 4 mg/kg/day or placebo. In each rat, a colonic anastomosis was performed and an expanded polytetrafluoroethylene (ePTFE) tube was placed subcutaneously. Incisional and anastomotic wound breaking strength and hydroxyproline content in the ePTFE tubes were measured 7 days after the operation. We found no significant differences in any of the breaking strength measurements, but showed a median 38% reduction in hydroxyproline deposition as a result of diclofenac treatment (p = 0.03). In the placebo group, subcutaneous collagen deposition tended to correlate positively with skin incisional but negatively with anastomotic bio-mechanical strength. Postoperative diclofenac treatment significantly inhibited collagen deposition in subcutaneous granula...Continue Reading

References

Mar 1, 1991·Diseases of the Colon and Rectum·W J MastboomH H de Boer
May 1, 1990·The Journal of Surgical Research·M J Koruda, R H Rolandelli
Oct 1, 1990·Diseases of the Colon and Rectum·T Hendriks, W J Mastboom
Jan 1, 1988·Journal of Biomechanics·C C Danielsen, T T Andreassen
Aug 13, 2002·International Journal of Colorectal Disease·I H J T de HinghT Hendriks
Oct 2, 2002·International Journal of Colorectal Disease·Peter MånssonHenrik Thorlacius
May 22, 2003·JPEN. Journal of Parenteral and Enteral Nutrition·Marco Aurelio Raeder da CostaHelim Minoru Matsumoto
Jan 1, 1962·Acta Pathologica Et Microbiologica Scandinavica·J VILJANTO, E KULONEN
Oct 27, 2004·The British Journal of Surgery·R A CahillH P Redmond
Feb 17, 2005·The New England Journal of Medicine·Nancy A NussmeierKenneth M Verburg
Sep 29, 2006·World Journal of Gastroenterology : WJG·Konstantinos A EkmektzoglouDespina N Perrea
Jul 1, 1995·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·C WickeT K Hunt
Feb 7, 2007·Diseases of the Colon and Rectum·Jacob Rosenberg, Thomas Harvald
Jun 20, 2008·International Journal of Colorectal Disease·M S AgrenL N Jorgensen
Jul 25, 2008·Annals of Surgery·Henrik Kehlet, Douglas W Wilmore
Jan 23, 2010·Cardiovascular & Hematological Disorders Drug Targets·Florian Krötz, Lena Struthmann
Apr 17, 2010·Annals of Surgery·Patricia L DanielsenLars N Jorgensen
Dec 8, 2010·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M KleinJ Rosenberg

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Citations

Jun 11, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jhananiee SubendranAnand Govindarajan
Mar 11, 2016·International Journal of Colorectal Disease·Joanna W A M BosmansNicole D Bouvy
May 5, 2016·Surgery Research and Practice·Stamatoula DrakopoulouGeorgios P Fragulidis
Jul 1, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ramy BehmanJulie Hallet
Apr 8, 2014·La Presse médicale·Valérie Bitot, Marc Beaussier
Sep 3, 2013·The Medical Clinics of North America·Magnus Löndahl
Mar 16, 2017·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Ilhan OzgolMustafa Cikirikcioglu
Jul 30, 2014·Nature Reviews. Gastroenterology & Hepatology·Julie Ann M Van Koughnett, Steven D Wexner
Jun 25, 2015·Annals of Surgery·Meera KotagalDavid R Flum
Mar 1, 2020·Journal of the American College of Surgeons·John W KunstmanRonald R Salem
Jun 3, 2021·Journal of Clinical Medicine·Stephan A Schug

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