PMID: 7544219Jul 1, 1995Paper

Effect of postoperative insulin-like growth factor I supplementation on protein metabolism in humans

The British Journal of Surgery
T LeinsköldJ Larsson

Abstract

Insulin-like growth factor I (IGF-I) has been shown experimentally to exert a nitrogen-sparing effect in both animals and humans. Its effects on protein metabolism during the first 5 days after radical large bowel resection were investigated. Nineteen patients were randomly allocated to receive either human recombinant IGF-I (2 x 80 micrograms/kg body weight subcutaneously, n = 10) or placebo (n = 9) starting on the morning of the first day after operation. All patients received parenteral nutrition (glucose 3 g and nitrogen 0.1 g/kg/day). The mean(s.e.m.) urinary nitrogen:creatinine ratio was significantly reduced in patients who received IGF-I compared with those given placebo (275.0(17.1) compared with 386.3(23.6), P < 0.01). The mean urinary 3-methylhistidine:creatinine ratio and nitrogen balance were lower in the IGF-I group, but not significantly so. Plasma IGF-I concentrations were four times higher in the treated group compared with those in the placebo group. Insulin-like growth factor binding protein 3 (IGFBP-3) increased significantly after the start of IGF-I treatment, compared with mean postoperative levels. The mean blood glucose concentration was significantly lower in the IGF-I group than the placebo group (P < ...Continue Reading

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Citations

Jun 1, 1997·Disease-a-month : DM·B A Mizock, S Troglia
May 20, 1998·Baillière's Clinical Endocrinology and Metabolism·C BotfieldC J Hinds
Jun 24, 1999·Cytokine & Growth Factor Reviews·V H HeemskerkW A Buurman
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Aug 28, 2010·Journal of Nutrition and Metabolism·Folke HammarqvistJan Wernerman
Nov 5, 1997·JPEN. Journal of Parenteral and Enteral Nutrition·C H FangP O Hasselgren
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Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melanie B GillinghamDenise M Ney
Jan 14, 1999·The American Journal of Physiology·I Castilla-CortázarJ Prieto
Sep 14, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·R C BaxterS R Holman

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