PMID: 6405838May 1, 1983Paper

Effect of postoperative total parenteral nutrition (TPN) as an adjunct to gastrectomy for advanced gastric carcinoma

The British Journal of Surgery
N YamadaM Yamamoto

Abstract

Clinical staging and immune reactivity were correlated in 39 patients who underwent gastrectomy for primary gastric cancer. Cellular immunity was depressed as the stage of cancer advanced, whereas humoral immunity was unaffected. Gastrectomy for advanced cancer in stage 3 and 4 suppressed cellular immunity. The cellular and humoral immune systems in relation to total parenteral nutrition (TPN) versus non-TPN were evaluated in 57 patients who underwent gastrectomy for stage 3 and 4 advanced cancer. Cell-mediated immunocompetence was restored in all 29 patients who received postoperative TPN, while serum immunoglobulins were unaffected by TPN. Improvement of impaired cell-mediated immunity was also obtained in patients treated with a TPN-5-FU combination as an adjunct to surgery. Treatment with TPN during 5-FU administration restored immunocompetence, increased tolerance for 5-FU and gave a satisfactory 3-year survival rate. There were significant differences in the 3-year survival rates of patients who underwent non-curative gastrectomy (54 per cent for TPN-5-FU v. 0 per cent for non-TPN-5-FU; P less than 0.05). It is concluded that TPN during chemotherapy as an adjunct to surgery leads to diminished morbidity, and possibly to p...Continue Reading

References

Mar 1, 1977·The Journal of Surgical Research·D M OtaS J Dudrick
May 1, 1979·Cancer·A Theologides
Apr 1, 1975·The Journal of Surgical Research·E SteigerH M Vars
Jan 1, 1976·Annals of the New York Academy of Sciences·C M PinskyH Oettgen
Feb 27, 1975·The New England Journal of Medicine·R L GrossP M Newberne
Feb 27, 1975·The New England Journal of Medicine·H H FudenbergD Robbins
Oct 1, 1975·American Journal of Surgery·H J WaneboH Oettgen
Oct 1, 1972·The Journal of Clinical Investigation·J WybranH H Fudenberg
Jan 1, 1974·Annals of the New York Academy of Sciences·C Waterhouse
Apr 5, 1973·The New England Journal of Medicine·J WybranH H Fudenberg
Oct 1, 1973·Archives of Surgery·A B CosimiB N Miller
Mar 1, 1973·The Japanese Journal of Surgery
Nov 1, 1971·The New England Journal of Medicine·E M HershE J Freireich

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Citations

Sep 21, 2000·The Proceedings of the Nutrition Society·D K Heyland
Dec 16, 2005·The New England Journal of Medicine·David CasarettArthur Caplan
Jul 29, 2005·The Proceedings of the Nutrition Society·Ronald L Koretz
Oct 7, 2003·Annual Review of Nutrition·Lyn Howard, Christopher Ashley
Jun 1, 1996·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S D HeysO Eremin
Oct 24, 2009·The Nursing Clinics of North America·Cheryl Monturo, Kevin Hook
Nov 21, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Andrea Kopp LugliFranco Carli
May 26, 2007·Journal of the American Dietetic Association·Ronald L Koretz
Mar 1, 1990·American Journal of Surgery·M M MeguidW G Hammond
Aug 29, 2009·JPEN. Journal of Parenteral and Enteral Nutrition·David Allen AugustUNKNOWN American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors
Jan 1, 1993·Critical Reviews in Clinical Laboratory Sciences·P W Pisters, D B Pearlstone
Jun 1, 1994·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·S Klein, R L Koretz
May 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·H YamanakaM Yamamoto
May 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·G L Hill
Jul 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·E M Copeland
Jan 19, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·F BozzettiS Piacenza
Jul 17, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Maureen B Huhmann, David A August
Sep 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·K G Lundholm, C Drott
May 20, 2017·The Cochrane Database of Systematic Reviews·Joshua FeinbergJanus C Jakobsen
Jul 1, 1992·The British Journal of Surgery·S D HeysO Eremin
Jun 1, 1986·The British Journal of Surgery·J R MonsonP J Guillou

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