Effect of postural change on urine volume and urinary sodium excretion in diabetic nephropathy

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
M OgiM Kuramochi

Abstract

Fluid retention develops relatively early in the renal insufficiency of patients with diabetic nephropathy. The objective of this study was to clarify the effect of postural change on urine volume and urinary sodium excretion in diabetic nephropathy. Subjects consisted of 16 patients with non-insulin-dependent diabetes mellitus (five with diabetic nephrotic syndrome [DNS], five with nonnephrotic overt diabetic nephropathy [NNODN], and six without overt diabetic nephropathy [ODN]) and 11 patients with nondiabetic renal diseases (five with nondiabetic nephrotic syndrome [NDNS] and six without nephrotic syndrome). Patients were studied during 60 minutes of recumbency, followed by 60 minutes of standing. Mean blood pressure decreased in the standing posture only in patients with DNS and nondiabetic renal diseases. Urine volume decreased in the standing posture in the three groups of diabetic patients. Urine volume showed no changes in the standing posture in nondiabetic patients with and without nephrotic syndrome. The decreases in mean blood pressure and urine volume and the percentage decrease in creatinine clearance were significantly larger in patients with DNS than in those with NDNS and NNODN. The increase in free water clear...Continue Reading

Citations

Sep 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R MinutoloD Russo
May 15, 2013·Diabetes, Obesity & Metabolism·H J Lambers HeerspinkJ List
Mar 24, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shigeto MorimotoMasayuki Matsumoto
Jan 8, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Pitchal BalakumarManjeet Singh
Apr 5, 2017·The Journal of Medical Investigation : JMI·Sakiya YoshimotoToshio Doi

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