Effect of potassium depletion on renal tubular function in the rat

Clinical Science
S J WalterD G Shirley

Abstract

1. In order to investigate the effects of K+ depletion on renal function, micropuncture studies were performed on anaesthetized rats which had been kept on a K+-deficient diet for 2 weeks; results were compared with those from control animals. 2. In the K+-depleted animals, values for total glomerular filtration rate and single-nephron filtration rate were significantly lower than in controls. Urine osmolality was also reduced; this was associated with reductions in the osmolality, Na+ concentration and K+ concentration of papillary interstitial fluid. No significant difference between urine and papillary osmolality was observed. 3. Fractional reabsorption by the proximal convoluted tubule was enhanced in the K+-depleted animals; end-proximal fluid delivery was markedly reduced. 4. Absolute, but not fractional, delivery of K+ to the beginning of the distal tubule was reduced in the K+-depleted animals. In contrast to observations in control rats, no net secretion of K+ into the distal tubule occurred and there was indirect evidence of K+ reabsorption in the collecting duct. 5. K+ depletion was associated with reductions in the delivery of Na+ and water to early and late regions of the distal tubule, whereas excretion rates of N...Continue Reading

References

Jun 15, 1997·The Journal of Physiology·D G Shirley, S J Walter
Jul 28, 2001·Kidney International·H K ZajicekM Levi
Feb 24, 2004·Annual Review of Physiology·WenHui Wang
Sep 2, 2008·Annual Review of Physiology·Jang H Youn, Alicia A McDonough
Apr 1, 1990·Pflügers Archiv : European journal of physiology·D G ShirleyS J Walter
Jan 18, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Klaus Thomsen, D G Shirley
Jun 3, 2000·American Journal of Physiology. Renal Physiology·P A MennittL G Palmer
Apr 14, 2020·American Journal of Physiology. Renal Physiology·Cary R Boyd-ShiwarskiArohan R Subramanya
Jun 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation· Hla-Yee-YeeG A MacGregor
Oct 22, 2002·American Journal of Physiology. Renal Physiology·Marie-Louise ElkjaerSøren Nielsen
Apr 13, 2012·American Journal of Physiology. Renal Physiology·Mien T X NguyenAlicia A McDonough
Aug 28, 2020·American Journal of Physiology. Cell Physiology·Brandon E McFarlinAlicia A McDonough

Related Concepts

Urine
Kidney Function Tests
Micropunctures
Filtration
Potassium Deficiency
Loop of Henle
Potassium
Potassium Depletion
Renal Tubule Structure
Distal Convoluted Renal Tubule Structure

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