Effect of potassium depletion on renal tubular function in the rat

Clinical Science
S J WalterD G Shirley


1. In order to investigate the effects of K+ depletion on renal function, micropuncture studies were performed on anaesthetized rats which had been kept on a K+-deficient diet for 2 weeks; results were compared with those from control animals. 2. In the K+-depleted animals, values for total glomerular filtration rate and single-nephron filtration rate were significantly lower than in controls. Urine osmolality was also reduced; this was associated with reductions in the osmolality, Na+ concentration and K+ concentration of papillary interstitial fluid. No significant difference between urine and papillary osmolality was observed. 3. Fractional reabsorption by the proximal convoluted tubule was enhanced in the K+-depleted animals; end-proximal fluid delivery was markedly reduced. 4. Absolute, but not fractional, delivery of K+ to the beginning of the distal tubule was reduced in the K+-depleted animals. In contrast to observations in control rats, no net secretion of K+ into the distal tubule occurred and there was indirect evidence of K+ reabsorption in the collecting duct. 5. K+ depletion was associated with reductions in the delivery of Na+ and water to early and late regions of the distal tubule, whereas excretion rates of N...Continue Reading


Jun 15, 1997·The Journal of Physiology·D G Shirley, S J Walter
Jul 28, 2001·Kidney International·H K ZajicekM Levi
Feb 24, 2004·Annual Review of Physiology·WenHui Wang
Sep 2, 2008·Annual Review of Physiology·Jang H Youn, Alicia A McDonough
Apr 1, 1990·Pflügers Archiv : European journal of physiology·D G ShirleyS J Walter
Jan 18, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Klaus Thomsen, D G Shirley
Jun 3, 2000·American Journal of Physiology. Renal Physiology·P A MennittL G Palmer
Apr 14, 2020·American Journal of Physiology. Renal Physiology·Cary R Boyd-ShiwarskiArohan R Subramanya
Jun 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation· Hla-Yee-YeeG A MacGregor
Oct 22, 2002·American Journal of Physiology. Renal Physiology·Marie-Louise ElkjaerSøren Nielsen
Apr 13, 2012·American Journal of Physiology. Renal Physiology·Mien T X NguyenAlicia A McDonough
Aug 28, 2020·American Journal of Physiology. Cell Physiology·Brandon E McFarlinAlicia A McDonough

Related Concepts

Kidney Function Tests
Potassium Deficiency
Loop of Henle
Potassium Depletion
Renal Tubule Structure
Distal Convoluted Renal Tubule Structure

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.