PMID: 6837736Apr 1, 1983

Effect of potassium on renal NH3 production

The American Journal of Physiology
S Sastrasinh, R L Tannen


The influence on renal ammoniagenesis of a high potassium diet and also of acute manipulation of ambient potassium concentration was investigated using both the isolated perfused rat kidney and incubated renal cortical tubules. Ingestion of a high potassium diet for 1 wk resulted in potassium adaptation but had no effect on ammonia production by the isolated kidney perfused with physiologic concentrations of glutamine. By contrast, perfusion with a high ambient potassium concentration (8.0-9.3 mM) significantly increased renal tissue potassium levels and concomitantly reduced the rate of ammonia formation by 30% in comparison with perfusions at a normal potassium concentration. NH3 production by tubules incubated with 1 mM glutamine was also decreased at a K+ concentration of 9.0 mM. Ammonia production was unchanged when kidneys were perfused with a potassium concentration of 2.0 mM despite a 16% decrease in renal tissue potassium levels, but ammonia production by tubules incubated in 2 mM K+ was slightly less than in control incubations at 5.0 mM. Thus, unlike earlier in vitro studies with outer medullary slices, these studies do not support the hypothesis that an adaptive change in ammoniagenesis results from a high dietary p...Continue Reading


Aug 18, 2017·Physiology·Julian L Seifter, Hsin-Yun Chang

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