Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study

Lancet
Salim YusufINTERHEART Study Investigators

Abstract

Although more than 80% of the global burden of cardiovascular disease occurs in low-income and middle-income countries, knowledge of the importance of risk factors is largely derived from developed countries. Therefore, the effect of such factors on risk of coronary heart disease in most regions of the world is unknown. We established a standardised case-control study of acute myocardial infarction in 52 countries, representing every inhabited continent. 15152 cases and 14820 controls were enrolled. The relation of smoking, history of hypertension or diabetes, waist/hip ratio, dietary patterns, physical activity, consumption of alcohol, blood apolipoproteins (Apo), and psychosocial factors to myocardial infarction are reported here. Odds ratios and their 99% CIs for the association of risk factors to myocardial infarction and their population attributable risks (PAR) were calculated. Smoking (odds ratio 2.87 for current vs never, PAR 35.7% for current and former vs never), raised ApoB/ApoA1 ratio (3.25 for top vs lowest quintile, PAR 49.2% for top four quintiles vs lowest quintile), history of hypertension (1.91, PAR 17.9%), diabetes (2.37, PAR 9.9%), abdominal obesity (1.12 for top vs lowest tertile and 1.62 for middle vs lowe...Continue Reading

Associated Clinical Trials

References

Feb 6, 1991·JAMA : the Journal of the American Medical Association·E L Barrett-ConnorS L Edelstein
Jul 7, 2000·The New England Journal of Medicine·M J StampferW C Willett
Jun 28, 2003·BMJ : British Medical Journal·N J Wald, M R Law
Aug 21, 2003·JAMA : the Journal of the American Medical Association·John G Canto, Ami E Iskandrian
Sep 18, 2003·Journal of the National Cancer Institute·Lawrence S EngelJoseph F Fraumeni
Nov 15, 2003·Lancet·Fiona Turnbull, UNKNOWN Blood Pressure Lowering Treatment Trialists' Collaboration
Jun 24, 2004·BMJ : British Medical Journal·Richard DollIsabelle Sutherland

❮ Previous
Next ❯

Citations

Jul 23, 2009·JAMA : the Journal of the American Medical Association·Luc DjousséJ Michael Gaziano
Nov 3, 2012·JAMA : the Journal of the American Medical Association·Martha L DaviglusJeremiah Stamler
Jun 29, 2006·JAMA : the Journal of the American Medical Association·Mary A Whooley
May 8, 2009·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·S S LiemM J Schalij
Jan 11, 2008·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·G Grande
Apr 9, 2010·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·T Lampert
Feb 4, 2011·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·C MeyerT Rassaf
May 25, 2013·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·C Scheidt-NaveM A Busch
Oct 30, 2012·Der Nervenarzt·L K KuehlC Otte
Jan 12, 2010·Der Urologe. Ausg. A·M Schubert, F Jockenhövel
Sep 5, 2012·Diabetologia·A Norhammar, K Schenck-Gustafsson
May 27, 2009·Social Psychiatry and Psychiatric Epidemiology·Christian A Falk Dahl, Alv A Dahl
Mar 2, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B B YeapP E Norman
Apr 21, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P WiklundP Nordström
Jun 17, 2009·European Journal of Clinical Pharmacology·Sylvie PerreaultDanielle Pilon
Mar 23, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Andor W J M GlaudemansAlberto Signore
Jan 9, 2007·Cardiovascular and Interventional Radiology·Anthony S Wierzbicki
Nov 1, 2005·Zeitschrift für Kardiologie·T Heitzer, T Meinertz
Oct 6, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Björn MayerHeribert Schunkert
Oct 3, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·H Völler
Apr 25, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Kishor LahiriUlrich Laufs
Apr 25, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Helmut Gohlke, Salim Yusuf
Aug 30, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·George BakrisFaiez Zannad
Mar 25, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Falk Müller-RiemenschneiderStefan N Willich
Jun 4, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Anselm K GittKurt Bestehorn
Feb 22, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·James D SargentReiner Hanewinkel
Mar 23, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christoph SinningStefan Blankenberg
Aug 20, 2011·Archives of Gynecology and Obstetrics·Suk Woo LeeJang Heup Kim
Sep 8, 2010·European Archives of Psychiatry and Clinical Neuroscience·Marc De HertJoseph Peuskens
Sep 2, 2011·European Journal of Applied Physiology·Thomas NickelH Hanssen
Jul 23, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Paloma BasTeresa Bas
Jul 21, 2012·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Fredrik Odegaard, Pontus Roos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.