Effect of pravastatin on left ventricular mass by activation of myocardial K ATP channels in hypercholesterolemic rabbits

Atherosclerosis
Tsung-Ming LeeNen-Chung Chang

Abstract

Epidemiological studies showed that hypercholesterolemia was associated with a higher left ventricular mass. Myocardial ATP-sensitive potassium (K(ATP)) channels have been implicated in the development of cardiac hypertrophy. We investigated the effect of pravastatin on hypercholesterolemia-induced ventricular hypertrophy and whether the attenuated hypertrophic effect was via activation of myocardial K(ATP) channels. In this study, we evaluated the hemodynamic, biochemical, and morphological responses to pravastatin in cholesterol-fed (1%) rabbits. Male New Zealand White rabbits were randomized to either vehicle, nicorandil (an agonist of K(ATP) channels), pravastatin, glibenclamide (an antagonist of K(ATP) channels), or a combination of nicorandil and glibenclamide or pravastatin and glibenclamide for 8 weeks. The left ventricular weight and left ventricular myocyte sizes increased 8 weeks after cholesterol-feeding in comparison to that in normocholesterolemic rabbits. Pravastatin administration significantly decreased the left ventricular weight by 12% and cardiomyocyte cell areas by 30%. Hyperlipidemic rabbits in the nicorandil- and pravastatin-treated groups significantly attenuated cardiomyocyte hypertrophy, as compared wi...Continue Reading

References

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Citations

Jul 25, 2007·Cardiovascular Toxicology·Simon W RabkinJennifer Y Kong
Jun 10, 2011·International Journal of Cardiology·Gert KlugBernhard Metzler
May 1, 2007·Journal of Molecular and Cellular Cardiology·M VaqueroE Delpón
Feb 9, 2007·Pharmacology & Therapeutics·Juan TamargoEva Delpón
Jun 24, 2009·IUBMB Life·Irena Levitan
Aug 19, 2007·European Journal of Clinical Investigation·F Simko
Jan 13, 2010·Acta Ophthalmologica·Blanca RojasJose M Ramírez
Apr 25, 2006·Diabetes Research and Clinical Practice·Nan-Hung PanNen-Chung Chang
Mar 29, 2008·Journal of the American College of Cardiology·Tsung-Ming LeeNen-Chung Chang
Jul 2, 2015·Brazilian Journal of Biology = Revista Brasleira De Biologia·D B SilvaJ A D Garcia
Mar 10, 2019·Fundamental & Clinical Pharmacology·Muhammed Fatih DoganKemal Gokhan Ulusoy
Jun 27, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Tsung-Ming LeeNen-Chung Chang
Sep 25, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Tsung-Ming LeeNen-Chung Chang
Aug 29, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Tsung-Ming LeeNen-Chung Chang

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