[Effect of pre-administered flurbiprofen axetil on the EC50 of propofol during anesthesia in unstimulated patients: a randomized clinical trial].

Revista brasileira de anestesiologia
Jing MaYan-Lin Wang

Abstract

Preoperative use of flurbiprofen axetil (FA) is extensively adopted to modulate the effects of analgesia. However, the relationship between FA and sedation agents remains unclear. In this study, we aimed to investigate the effects of different doses of FA on the median Effective Concentration (EC50) of propofol. Ninety-six patients (ASA I or II, aged 18-65 years) were randomly assigned into one of four groups in a 1:1:1:1 ratio. Group A (control group) received 10 mL of Intralipid, and groups B, C and D received 0.5 mg.kg-1, 0.75 mg.kg-1 and 1 mg.kg-1 of FA, respectively, 10 minutes before induction. The depth of anesthesia was measured by the Bispectral Index (BIS). The "up-and-down" method was used to calculate the EC50 of propofol. During the equilibration period, if BIS ≤ 50 (or BIS > 50), the next patient would receive a 0.5 μg.mL-1-lower (or-higher) propofol Target-Controlled Infusion (TCI) concentration. The hemodynamic data were recorded at baseline, 10 minutes after FA administration, after induction, after intubation, and 15 minutes after intubation. The EC50 of propofol was lower in Group C (2.32 μg.mL-1, 95% Confidence Interval [95% CI] 1.85-2.75) and D (2.39 μg.mL-1, 95% CI 1.91-2.67) than in Group A (2.96 μg.mL-1,...Continue Reading

References

Jan 1, 1991·Neuroscience and Biobehavioral Reviews·W J Dixon
Jun 1, 1989·British Journal of Clinical Pharmacology·K R SweeneyP A Kramer
May 8, 1985·European Journal of Pharmacology·M C Wallenstein
Dec 1, 1995·British Journal of Clinical Pharmacology·J LötschG Kobal
Mar 12, 1999·British Journal of Clinical Pharmacology·J X Mazoit, K Samii
Dec 20, 2007·The Journal of Pharmacy and Pharmacology·Kenji OgataShun Higuchi
Jul 2, 2008·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Yajun XuWei Chen
Nov 6, 2009·Pflügers Archiv : European journal of physiology·Hongzhen HuMichael X Zhu
Jun 22, 2013·Journal of Clinical Nursing·Asa Wallström, Gunilla Hollman Frisman
Jun 18, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Lieliang ZhangHongguang Bao
Mar 20, 2016·Revista brasileira de anestesiologia·Supriya AggarwalAlok Kumar
Mar 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hoai T TonGerard P Ahern
Feb 16, 2018·F1000Research·Pei Tang, Roderic Eckenhoff
Oct 1, 2018·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xinjin ChiZiqing Hei

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