Effect of Prebiotic Galacto-Oligosaccharides on Serum Lipid Profile of Hypercholesterolemics

Probiotics and Antimicrobial Proteins
Arooj HashmiRahat Naseer

Abstract

The present study focused on the role of galacto-oligosaccharides (GOS) against the development of hypercholesterolemia. In the current research, GOS synthesized from lactose solution were fed to hypercholesterolemic female Sprague-Dawley rats. Negative control group (G1) was fed on standard basal diet alone. Positive control group (G5) was fed on inulin (154 mg/250 g body weight), while treatment groups G2, G3 and G4 received 110 mg, 154 mg and 198.4 mg/250 g body weight, respectively, of GOS along with high-fat diet for a period of 60 days. Findings from this study revealed that animals belonging to prebiotic GOS (G2, G3 and G4)-fed group showed significantly decreased serum triglycerides, total cholesterol, LDL cholesterol and VLDL cholesterol as compared to control group (G0). The groups which were fed on different doses of GOS revealed a significant reduction in TC, TG, LDL, and VLDL levels and an increase in HDL level corresponding to the reference group that was fed on inulin, while G1 negative control group revealed increased levels of TC, TG, LDL and VLDL. In contrast to positive control group G5 (154 mg inulin), all doses of GOS lowered serum TC, TG and LDL-C and raised HDL-C; however, G4 (198.4 mg) proved to be more ...Continue Reading

References

Jun 1, 1995·The Journal of Nutrition·G R Gibson, M B Roberfroid
Nov 1, 1995·Critical Reviews in Food Science and Nutrition·J van LooG Smits
Oct 31, 2001·The American Journal of Clinical Nutrition·E Dewailly EB J Holub
Sep 6, 2003·Lancet·Paul Durrington
Oct 4, 2003·Biotechnology Progress·B Mattheus de RoodeRemko M Boom
Aug 3, 2005·Journal of Lipid Research·Makoto AsahinaKatsumi Imaizumi
Jul 10, 2007·Metabolism: Clinical and Experimental·Fabien Forcheron, Michel Beylot
Dec 1, 2004·Nutrition Research Reviews·Glenn R GibsonMarcel B Roberfroid
Mar 31, 2009·Journal of Agricultural and Food Chemistry·Wei LiXiaoxiong Zeng
Sep 1, 2010·Comprehensive Reviews in Food Science and Food Safety·Duarte P M TorresLígia R Rodrigues

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Citations

Nov 13, 2020·Expert Opinion on Therapeutic Targets·Mohammad BadranDavid Gozal
Jan 12, 2022·Journal of Agricultural and Food Chemistry·Virginia Blanco-MoralesGuadalupe Garcia-Llatas

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