Abstract
The present study focused on the role of galacto-oligosaccharides (GOS) against the development of hypercholesterolemia. In the current research, GOS synthesized from lactose solution were fed to hypercholesterolemic female Sprague-Dawley rats. Negative control group (G1) was fed on standard basal diet alone. Positive control group (G5) was fed on inulin (154 mg/250 g body weight), while treatment groups G2, G3 and G4 received 110 mg, 154 mg and 198.4 mg/250 g body weight, respectively, of GOS along with high-fat diet for a period of 60 days. Findings from this study revealed that animals belonging to prebiotic GOS (G2, G3 and G4)-fed group showed significantly decreased serum triglycerides, total cholesterol, LDL cholesterol and VLDL cholesterol as compared to control group (G0). The groups which were fed on different doses of GOS revealed a significant reduction in TC, TG, LDL, and VLDL levels and an increase in HDL level corresponding to the reference group that was fed on inulin, while G1 negative control group revealed increased levels of TC, TG, LDL and VLDL. In contrast to positive control group G5 (154 mg inulin), all doses of GOS lowered serum TC, TG and LDL-C and raised HDL-C; however, G4 (198.4 mg) proved to be more ...Continue Reading
References
Feb 1, 1995·Lipids·M FiordalisoN Delzenne
Jun 1, 1995·The Journal of Nutrition·G R Gibson, M B Roberfroid
Nov 1, 1995·Critical Reviews in Food Science and Nutrition·J van LooG Smits
Nov 15, 1997·Journal of Dairy Science·S H KimH S Kim
Jun 28, 2001·Physiological Reviews·D L Topping, P M Clifton
Oct 31, 2001·The American Journal of Clinical Nutrition·E Dewailly EB J Holub
May 31, 2002·The American Journal of Clinical Nutrition·Thomas M S WoleverMichael I McBurney
Sep 27, 2002·The British Journal of Nutrition·Katharina E Scholz-AhrensJürgen Schrezenmeir
Sep 6, 2003·Lancet·Paul Durrington
Oct 4, 2003·Biotechnology Progress·B Mattheus de RoodeRemko M Boom
Oct 19, 2004·Nutrition and Cancer·Annett KlinderBeatrice L Pool-Zobel
Aug 3, 2005·Journal of Lipid Research·Makoto AsahinaKatsumi Imaizumi
Dec 5, 2006·International Journal of Food Microbiology·T D T NguyenM S Lee
Jul 10, 2007·Metabolism: Clinical and Experimental·Fabien Forcheron, Michel Beylot
Dec 1, 2004·Nutrition Research Reviews·Glenn R GibsonMarcel B Roberfroid
Mar 31, 2009·Journal of Agricultural and Food Chemistry·Wei LiXiaoxiong Zeng
Dec 24, 2010·FEMS Microbiology Letters·Clarissa Schwab, Michael Gänzle
Mar 17, 2011·Journal of Agricultural and Food Chemistry·Sanaullah IqbalDietmar Haltrich
Sep 1, 2010·Comprehensive Reviews in Food Science and Food Safety·Duarte P M TorresLígia R Rodrigues
Citations
Mar 30, 2018·Food & Function·Virginia Blanco-MoralesAmparo Alegría
May 24, 2018·Food & Function·E KorczL Varga
Jul 18, 2018·Frontiers in Immunology·Haidong TanKuikui Li
Nov 16, 2019·European Journal of Nutrition·Mahdieh Abbasalizad FarhangiNazli Namazi
Jul 18, 2017·Frontiers in Pharmacology·Hoda M EidPierre S Haddad
Nov 13, 2020·Expert Opinion on Therapeutic Targets·Mohammad BadranDavid Gozal
May 22, 2021·Epilepsy Research·Ju Young EorSae Hun Kim
Jan 12, 2022·Journal of Agricultural and Food Chemistry·Virginia Blanco-MoralesGuadalupe Garcia-Llatas