Effect of Prednisolone Administration on Patients with Unexplained Recurrent Miscarriage and in Routine Intracytoplasmic Sperm Injection: A Meta-Analysis

American Journal of Reproductive Immunology : AJRI
Song DanLi Hong

Abstract

The effects of prednisolone on pregnancy outcome are open to debate. This meta-analysis was performed to evaluate the efficiency of prednisolone administration on unexplained recurrent miscarriage (RM) and the process of assisted reproductive technology (ART). Relevant publications were searched from databases and the included randomized controlled trials (RCTs) investigated effects of prednisolone administration in women with unexplained RM or during ART. The outcomes in our analysis were measured in terms of risk ratios (RRs) with 95% confidence intervals (CI) using random effect models. This meta-analysis was performed based on pregnancy outcomes following prednisolone treatment. This meta-analysis provides evidence that prednisolone therapy improves pregnancy outcomes in women with idiopathic RM (live birth rate: RR 1.58, 95% CI 1.23-2.02; successful pregnancy outcome: RR 7.63, 95% CI 3.71-15.69; miscarriage rate: RR 0.42, 95% CI 0.28-0.61). Our meta-analysis revealed a non-significant effect of prednisolone on pregnancy outcome during intracytoplasmic sperm injection (ICSI) cycles (pregnancy rate: RR 1.02, 95% CI 0.84-1.24; clinical pregnancy rate: RR 1.01, 95% CI 0.82-1.24; implantation rate: RR 1.04, 95% CI 0.85-1.28). P...Continue Reading

References

Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·R S AddisonG R Cannell
Sep 5, 2002·Nature Reviews. Immunology·Ashley Moffett-King
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Teresa A HendersonHilary O D Critchley
Dec 4, 2003·Human Reproduction·Siobhan QuenbyGill Vince
Nov 27, 2004·BMJ : British Medical Journal·Ashley MoffettPeter Braude
Feb 16, 2008·American Journal of Reproductive Immunology : AJRI·Meen-Yau ThumAmolak Bansal
Jul 12, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M Krigstein, G Sacks
Jul 10, 2013·Human Fertility : Journal of the British Fertility Society·Charalampos SiristatidisDemetrios Kassanos
Aug 26, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Beiyu LiuT C Li

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Citations

Nov 26, 2015·Journal of Reproductive Immunology·Ai-Min ZhaoLi-Ming Lu
Apr 26, 2016·American Journal of Reproductive Immunology : AJRI·Paola TriggianeseRoberto Perricone
Nov 5, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Samaneh Abdolmohammadi-VahidMehdi Yousefi
May 8, 2020·Upsala Journal of Medical Sciences·Luciano Nardo, Spyridon Chouliaras
Feb 3, 2021·Human Reproduction Update·Indra Díaz-HernándezFrancisco Domínguez
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Eliza GrbacEllen Menkhorst
Dec 19, 2021·American Journal of Reproductive Immunology : AJRI·Carolina CarneiroRicardo Barini

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