PMID: 19459500May 23, 2009Paper

Effect of pregnancy on the immune response against Trichinella spiralis infection in mice

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases
Yan-juan WangZhong-quan Wang

Abstract

To study the effect of pregnancy on the immune response against Trichinella spiralis infection in mice. Six pregnant mice were orally infected each with 300 muscle larvae of T. spiralis, and the serum anti-Trichinella antibodies at different time after infection were detected by ELISA. The mice were sacrificed 6 weeks after infection and the carcass was digested to observe the muscle larval burden (larvae per gram, lpg). The ability of sera from infected pregnant mice to mediate the death of pre-encapsulated larvae (PEL) were assayed in an antibody-dependent cell-mediated cytotoxicity (ADCC). On 6th, 8th and 12th day after infection, the infected pregnant mice were sacrificed to examine the intestinal worm burden and the fecundity index of female worms in vitro. Six virgin mice injected with progesterone were infected with T. spiralis, the serum antibodies and muscle larval burden were detected 6 weeks after infection. The absorbance value of sera from pregnant mice (0.113) were significantly higher than that from virgin mice (0.078) at 2 weeks after infection (F=21.390, P<0.05). The muscle larval burden in pregnant mice (1251 +/- 450 lpg) was significantly lower than that of virgin mice (2310 +/- 1123 lpg) 6 weeks after infect...Continue Reading

Related Concepts

Helminth Antibodies
Mice, Inbred Strains
Human Trichinellosis
Pregnancy Complications, Parasitic
Antibody-Dependent Cellular Cytotoxicity
Enzyme-Linked Immunosorbent Assay
Intestines
Larva
Laboratory mice
Muscle

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