Effect of prehospital induction of mild hypothermia on 3-month neurological status and 1-year survival among adults with cardiac arrest: long-term follow-up of a randomized, clinical trial

Journal of the American Heart Association
Charles MaynardFrancis Kim

Abstract

Randomized trials of prehospital cooling after cardiac arrest have shown that neither prehospital cooling nor targeted temperature management differentially affected short-term survival or neurological function. In this follow-up study, we assess the association of prehospital hypothermia with neurological function at least 3 months after cardiac arrest and survival 1 year after cardiac arrest. There were 508 individuals who were discharged alive from hospitals in King County, Washington; 373 (73%) were interviewed by telephone 123±43 days after the initial event. Overall, 59% of the treatment group and 58% of the control group had Cerebral Performance Category (CPC) 1 or 2 (P=0.70), and 50% of the treatment group and 49% of the control group had slight disability or better by the Modified Rankin Scale (MRS; (P=0.35). One-year survival was 87% in the treatment group and 84% in the control group (P=0.42). Of those with CPC 1 at hospital discharge, 68% had CPC 1 or 2 at follow-up, and 59% had MRS of slight disability or better. Of 41 patients with CPC 3 or 4 at discharge, only 12% had CPC 2 at follow-up, and just 5% had MRS of slight disability or better. One-year survival was 92% for CPC 1 at discharge, but only 40% for CPC 4. I...Continue Reading

Associated Clinical Trials

References

Feb 22, 2002·The New England Journal of Medicine·UNKNOWN Hypothermia after Cardiac Arrest Study Group
Feb 22, 2002·The New England Journal of Medicine·Stephen A BernardKaren Smith
Nov 19, 2013·The New England Journal of Medicine·Niklas NielsenUNKNOWN TTM Trial Investigators
Jun 10, 2014·Resuscitation·Stefanie G BeesemsRudolph W Koster

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Citations

Feb 2, 2016·Therapeutic Hypothermia and Temperature Management·Patrick D LydenAndrew W Kiragu
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Omar TujjarFabio Silvio Taccone
Nov 16, 2018·Therapeutic Hypothermia and Temperature Management·Graham NicholGregory Kapinos
Jan 14, 2020·Therapeutic Hypothermia and Temperature Management·Graham NicholMarkus Ferrari
Dec 15, 2017·Anesthesia and Analgesia·Rajat KalraNavkaranbir S Bajaj
May 25, 2018·Therapeutic Hypothermia and Temperature Management·Hans FribergTakahiro Nakashima
Mar 29, 2021·Resuscitation·Jasmeet SoarJerry P Nolan
Apr 9, 2021·Journal of Pharmacy Practice·John R CarrUNKNOWN University of Georgia College of Pharmacy Critical Care Collaborative (UGAC3).
Jun 15, 2021·Notfall & Rettungsmedizin·Jasmeet SoarJerry P Nolan
Sep 3, 2021·Resuscitation·Asger GranfeldtUNKNOWN International Liaison Committee on Resuscitation (ILCOR) Advanced Life Support Task Force

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