PMID: 6129142Oct 1, 1982

Effect of prenalterol in asthmatic patients

European Journal of Clinical Pharmacology
C G Löfdahl, N Svedmyr


The bronchial effects of prenalterol, a selective inotropic beta-adrenoceptor agonist, were examined to see whether beta 1-adrenoceptor stimulation would produce bronchodilatation, or whether beta 2-adrenoceptor blockade could be demonstrated. In a first investigation 8 asthmatic patients were studied under standardized conditions in a double-blind, randomized, crossover comparison between i.v. doses of prenalterol and saline infusions. After the fourth dose of prenalterol/saline, 4 intravenous doses of terbutaline were given. All medication was given at 30 min intervals. In a second study in 7 of the previously studied patients, 5 increasing doses of prenalterol or saline were inhaled from a bird ventilator, and after the last dose 4 i.v. doses of terbutaline were given as before. Prenalterol and saline caused no change in FEV1 during the intravenous study. Terbutaline infusion produced a dose dependent increase in FEV1 which was not significantly altered after prenalterol treatment. In the inhalation study, in which a much larger dose was applied to the bronchial tree, there was no significant difference in FEV1, between the saline and prenalterol inhalations. However, prenalterol did show beta 2-blocking property, as the dos...Continue Reading


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Related Concepts

Adrenergic beta-Agonists
Aerosol Dose Form
Diastolic Blood Pressure
Dose-Response Relationship, Drug
Double-Blind Method
Forced Expiratory Volume Function
Pulse Rate
Parenteral Infusion

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