PMID: 6142747Mar 17, 1984

Effect of prenalterol on orthostatic hypotension in the Shy-Drager syndrome

British Medical Journal
J GoovaertsD Knockaert

Abstract

Treatment of idiopathic orthostatic hypotension is often unsatisfactory. A patient with the Shy-Drager syndrome, in which the most important symptom is orthostatic hypotension, was treated with prenalterol, initially 30 mg six times daily. The dosage was reduced to 30 mg four times daily because of the development of complex ventricular premature beats. Orthostatic symptoms were reduced and standing blood pressure increased. Fludrocortisone 0.5 mg a day was added to treatment with further improvement. This clinical effect was maintained throughout 12 months of follow up, during which the treatment was continued unchanged. Prenalterol was effective in reducing orthostatic symptoms in this patient. Further studies in patients with a similar haemodynamic pattern are indicated.

References

Oct 31, 1981·Lancet·B DaviesP Sever
Mar 21, 1981·British Medical Journal·A J Man in 't Veld, M A Schalekamp
Jun 26, 1980·The New England Journal of Medicine·A J MossE Topol
Sep 1, 1980·Archives of Internal Medicine·I J Schatz

Citations

Feb 14, 1987·British Medical Journal·R D Watson
Jun 1, 1987·Annals of Neurology·J G McLeod, R R Tuck
Oct 15, 1990·The Medical Journal of Australia·A L Tonkin, L M Wing

Related Concepts

Adrenergic beta-Agonists
Segmental Autonomic Dysfunction
Polychemotherapy
Astonin
Hemodynamics
Hypotension, Orthostatic
Dalzic
H-80-62
Shy-Drager Syndrome

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