PMID: 6405434Jan 1, 1983Paper

Effect of prenatal and postnatal exposure to therapeutic doses of chlorimipramine on emotionality in the rat

Psychopharmacology
E L Rodríguez Echandía, S T Broitman

Abstract

Prenatal administration of high doses of tricyclic antidepressants have been reported to produce teratogenic and behavioral effects in rat offspring. In the present work, behavioral abnormalities are described in offspring of rats treated with therapeutic doses of chlorimipramine (CIM) during pregnancy (CIM-P), lactation (CIM-L) and during the whole pregnancy-lactation period (CIM-PL). CIM-P treatment did not produce teratogenic effects, did not affect number or body weight of pups at birth and did not induce neonatal mortality. At 2 months of age, the CIM-P males showed a significant increase in digging and grooming (familiar environment test), a decrease in "exploration" (novel environment test) and a decrease in active social interactions (social behavior test). Females were more resistant than males to the prenatal CIM treatment. The results suggest increased emotionality in CIM-P pups. Some behavioral abnormalities were also observed in the tests performed at 4 months of age. CIM-L treatment had minor effects on litter behavior. CIM-PL treatment potentiated the effects of the CIM-P treatment. In the CIM-PL males, impairment of exploration of a novel environment still remained in the tests performed at 4 months of age. It i...Continue Reading

References

Dec 1, 1979·Journal of Affective Disorders·S E File, J R Hyde
Dec 1, 1979·Behavioral and Neural Biology·E J GreenT H Lanthorn
Sep 1, 1975·Pharmacology, Biochemistry, and Behavior·I R Coyle
Feb 1, 1974·Physiology & Behavior·S T Broitman, A O Donoso
Jan 1, 1968·Psychopharmacologia·J L CrammerB Rolfe
Nov 1, 1980·Physiology & Behavior·A S FlemingC Luebke
Jun 1, 1963·Transactions of the New York Academy of Sciences·H F HUNT, L S OTIS

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Citations

Aug 12, 2000·Stress : the International Journal on the Biology of Stress·A S González JatuffE L Rodríguez Echandía
May 1, 1986·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M Mirmiran
Feb 26, 2014·Pharmacological Reviews·Chase H BourkeMichael J Owens

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