Effect of prenatal dexamethasone on rat renal development

Kidney International
Luis A OrtizMichel Baum

Abstract

Prenatal insults can program the developing fetus to develop diseases that manifest in later life. Dexamethasone is often administered to the developing fetus to accelerate pulmonary development. The purpose of the present study was to determine whether prenatal dexamethasone adversely affects renal development and predisposes rats to develop renal disease and hypertension in later life. Pregnant rats were given either vehicle or two daily intraperitoneal injections of dexamethasone (0.2 mg/kg body weight) on gestational days: 11 and 12, 13 and 14, 15 and 16, 17 and 18, 19 and 20, or 20 and 21. Tail cuff blood pressure, glomerular number, and inulin clearance were measured in control and prenatal dexamethasone-treated rats when the rats were 60 to 90 days of age. Prenatal dexamethasone did not affect the length of gestation, the number of animals per litter, or the total body weight or kidney weight measured at one day of age. Offspring of rats administered dexamethasone on days 15 and 16 gestation had a 30% reduction in glomerular number compared with control at 60 to 70 days of age (24,236 +/- 441 vs. 30,453 +/- 579, P < 0.01). Rats receiving prenatal dexamethasone on days 17 and 18 had an approximate 20% reduction in glomeru...Continue Reading

References

Feb 1, 1977·American Journal of Obstetrics and Gynecology·M F EpsteinR A Chez
Apr 1, 1992·British Journal of Obstetrics and Gynaecology·S A HinchliffeD Van Velzen
Aug 4, 1990·BMJ : British Medical Journal·D J BarkerS J Simmonds
Oct 1, 1988·American Journal of Hypertension·B M BrennerS Anderson
Mar 1, 1980·Analytical Biochemistry·C Labarca, K Paigen
Jan 15, 1984·American Journal of Obstetrics and Gynecology·T E Bunton, C G Plopper
Apr 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·C Merlet-BénichouB Leroy
Feb 6, 1993·Lancet·R BenediktssonC R Edwards
Apr 10, 1993·Lancet·D J BarkerJ S Robinson
Feb 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B M Brenner, G M Chertow

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Citations

Apr 23, 2005·Cell and Tissue Research·Karen M MoritzE Marelyn Wintour
Mar 23, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Juan Rodríguez-SorianoAlfredo Vallo
Sep 18, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Wael A SeliemAlison L Kent
Jan 25, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Janis M DionneJoseph T Flynn
Mar 11, 2004·Current Hypertension Reports·Michelle M Kett, John F Bertram
Oct 9, 2002·Trends in Endocrinology and Metabolism : TEM·Miodrag DodicE Marelyn Wintour
Aug 1, 2010·Journal of Developmental Origins of Health and Disease·W E HoyJ F Bertram
Nov 17, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xue-Qin HaoXiao-Hui Li
Jan 25, 2003·Clinical and Experimental Pharmacology & Physiology·João P C MartinsAna D O Paixão
Jun 17, 2008·Human Reproduction Update·Anthony E Michael, Aris T Papageorghiou
Mar 1, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bridgette J McNamaraJohn F Bertram
Feb 16, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bridgette J McNamaraJohn F Bertram
Mar 18, 2003·Current Opinion in Pediatrics·Michel BaumAlbert Quan
Jun 17, 2004·Current Opinion in Nephrology and Hypertension·Julie R Ingelfinger
Sep 14, 2012·Clinical and Experimental Pharmacology & Physiology·Reetu R SinghKaren M Moritz
Nov 26, 2009·Clinical and Experimental Pharmacology & Physiology·Helena C ParkingtonMarianne Tare
Jul 15, 2005·Kidney International. Supplement·Valerie A Luyckx, Barry M Brenner
Jun 18, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lijun TangJames C Rose
Nov 28, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lijun TangJames C Rose
May 1, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Amit DaganMichel Baum
May 25, 2012·American Journal of Physiology. Renal Physiology·Louise C EvansMatthew A Bailey
Oct 2, 2009·American Journal of Physiology. Renal Physiology·Michel Baum
Jan 15, 2010·American Journal of Physiology. Renal Physiology·Stephen A ContagJames C Rose
Dec 23, 2011·American Journal of Physiology. Renal Physiology·Chih-Jen ChengMichel Baum
Dec 20, 2012·International Journal of Nephrology·Euming Chong, Ihor V Yosypiv
Jun 17, 2011·American Journal of Nephrology·Megan R SutherlandM Jane Black
Dec 6, 2005·Pediatric Research·Michiel F SchreuderHenriette A Delemarre-van de Waal
Jan 11, 2007·Pediatric Research·Patrick J G H KamphuisVictor M Wiegant
Sep 12, 2009·Pediatric Research·Willem B de VriesMatthijs F M van Oosterhout
Sep 11, 2010·Journal of the American Society of Nephrology : JASN·Stephen P GrayKaren M Moritz
Aug 29, 2014·Pediatric Research·Ruud R G BuetersMichiel F Schreuder
Aug 27, 2014·Clinics in Perinatology·Megan SutherlandAlison L Kent
Sep 18, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Batbayar Khulan, Amanda J Drake
Feb 22, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Xue-Qin HaoZhen-Sheng Zhao
Mar 2, 2010·Biochemical and Biophysical Research Communications·Julie E GoodwinDavid S Geller
Jul 21, 2009·Seminars in Nephrology·Carolyn L Abitbol, Julie R Ingelfinger

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