PMID: 9438520Jan 23, 1998Paper

Effect of prenatal ethanol exposure on fetal calcium metabolism

Alcoholism, Clinical and Experimental Research
K KeiverJ Weinberg

Abstract

Alcohol consumption has adverse effects on both adult and developing bone. The mechanisms by which alcohol affects bone, however, are unknown. This study examined the possibility that maternal alcohol consumption may affect fetal bone development by altering fetal levels of parathyroid hormone (PTH), 1,25(OH)2D, or calcitonin (hormones that regulate calcium (Ca) and bone metabolism in the adult animal). Female Sprague-Dawley rats were bred and divided into three groups: 1 group was fed lab chow ad libitum (Control; C) and the other 2 groups received a liquid diet with (Ethanol; E) or without (Pair-fed; PF) ethanol. Blood from dams and fetuses was collected on day 21 of gestation, and selected fetuses were stained for determination of the degree of bone ossification. Mean fetal body weight and fetal skeletal ossification were reduced in the E compared with PF and C groups. Total Ca levels in fetal serum, however, showed a trend to be increased in E compared with PF and C fetuses, and no significant group differences were found in fetal serum levels of albumin, PTH, or calcitonin. Serum levels of 25-OH-D and 1,25(OH)2D were significantly decreased in E and PF, compared with C fetuses. Total Ca levels in maternal serum did not var...Continue Reading

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Citations

Jun 1, 2005·Life Sciences·Thomas M BadgerMartin J Ronis
Jun 18, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ran Namgung, Reginald C Tsang
Dec 23, 2015·Birth Defects Research. Part A, Clinical and Molecular Teratology·Isabel Chaves Silva CarvalhoRosilene Fernandes da Rocha
Dec 24, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Elena S Vyatchanina
Nov 19, 2004·Developmental Psychobiology·Andrew P McMechanJohn H Hannigan
Jan 9, 2007·Alcoholism, Clinical and Experimental Research·Shalu DuggalKathy Keiver
May 8, 2013·Alcoholism, Clinical and Experimental Research·Onkar B SawantShannon E Washburn
Aug 27, 2016·The American Journal of Cardiology·Zhao LiMaria R Abraham
Jul 25, 2006·International Review of Cytology·Julie Lafond, Lucie Simoneau
Sep 27, 2016·Journal of Oral Science·Isabel C S CarvalhoRosilene F da Rocha
May 29, 2000·The Proceedings of the Nutrition Society·R Namgung, R C Tsang
Sep 25, 2003·Alcoholism, Clinical and Experimental Research·Kathy Keiver, Joanne Weinberg
Jan 28, 2004·Alcoholism, Clinical and Experimental Research·Kathy Keiver
Apr 16, 2004·Alcoholism, Clinical and Experimental Research·Kathy Keiver, Joanne Weinberg
Feb 2, 2008·Hippocampus·Andrea K Titterness, Brian R Christie

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