Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development.

Toxicology
Prajakta S PalkarJeffrey M Peters

Abstract

Recent work indicates that PPARalpha is required for perfluorooctanoic acid (PFOA)-induced postnatal lethality resulting from prenatal exposure. The present study tested the hypothesis that relatively modest activation of PPARalpha during prenatal development will cause postnatal lethality, similar to that observed with PFOA, a relatively low affinity PPARalpha agonist. Female wild-type and Pparalpha-null mice were mated overnight with males of the same genotype. The presence of a copulatory plug on the morning after mating was indicative of pregnancy and considered gestation day (GD) 0. Plugged female mice were fed either a control diet or one containing clofibrate (0.5%) or Wy-14,643 (0.005%) until GD18 or until parturition. Mice were examined on GD18 or on postnatal day (PND) 20 following the prenatal exposure period. Dietary administration of clofibrate or Wy-14,643 did not affect maternal weight or weight gain, the average number of implantations, the percentage of litter loss, the average number of live/dead fetuses, average crown-rump length, or the average fetal weight on GD18 in either genotype. An increase in relative maternal liver weight and elevated expression of PPARalpha target genes in maternal and fetal livers ...Continue Reading

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Citations

Nov 13, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Prajakta P AlbrechtJeffrey M Peters
Dec 11, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology
Nov 15, 2018·Drug and Chemical Toxicology·Vidhya Yarahalli JayaramRajyalakshmi Malempati

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