PMID: 6107343Oct 1, 1980Paper

Effect of prenatal phenytoin administration on brain tryptophan metabolism of rat offspring during the preweaning period

The Journal of Pharmacy and Pharmacology
M M Elmazar, F M Sullivan

Abstract

Serum 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) concentrations in control rat offspring increased progressively during the preweaning period reaching adult values by day 21. It has been shown the prenatal phenytoin administration (100 mg kg-1 orally, days 7-19 of pregnancy) increased serum tryptophan and brain tryptophan, 5-HT and 5-HIAA of rat offspring at 3 days of age but not at 4, 15 or 21 days of age. The effect of prenatal phenytoin administration on the offspring at 3 days of age was not observed when these pups were cross-fostered to control mothers at 2 days of age suggesting that the alteration in rain tryptophan metabolism during the development of tryptaminergic neurons in rat offspring, as a result of prenatal phenytoin administration is mediated through changes in lactation or nursing ability of the mothers. It is important that such non-specific factors are controlled when studying the effect of prenatally administered drugs on neonatal brain transmitter concentrations.

References

Mar 1, 1975·Lancet·D ChadwickE H Reynolds
Sep 1, 1975·The Journal of Pharmacy and Pharmacology·P JennerC D Marsden
Feb 1, 1975·Neuropharmacology·A R Green, D G Grahame-Smith
Nov 1, 1975·Animal Behaviour·J Altman, K Sudarshan
Oct 21, 1972·Lancet·B D Speidel, S R Meadow
Aug 1, 1974·Journal of Neurochemistry·S BourgoinM Hamon
Oct 20, 1972·Nature·P J Knott, G Curzon
Aug 1, 1972·Journal of Neurochemistry·G CurzonP J Knott

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