Effect of prenatal stress on ɑ5 GABAA receptor subunit gene expression in hippocampus and pilocarpine induced seizure in rats

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Mehrdad NejatbakhshMorteza Bagheri

Abstract

The GABAergic synapses go through structural and functional maturation during early brain development. Maternal stress alters GABAergic synapses in developing brain, which are associated with the pathophysiology of neuropsychiatric disorders in adults. The present study aimed to investigate the effect of prenatal restraint stress (PS) on pilocarpine-induced seizure and ɑ5 subunit of γ-amino butyric acid type A (GABAA) receptor expression in hippocampus. Pregnant Wistar rats were subjected to PS at gestational days 15-17 and the pups were examined for susceptibility to seizure and ɑ5 subunit of GABAA receptor expression in hippocampus at postnatal days 14 and 21 (P14 and PND 21). Quantitative real-time PCR was used for evaluating the gene expression in the pups. Pilocarpine was injected intraperitoneally into the pups and seizure behaviors were recorded. The results showed that ɑ5 subunit mRNA expression significantly increased in hippocampus at both the P14 and P21 in the stressed rats. However, ɑ5 subunit level was greater at the P21 than at the P14 in both the groups. Latency of first tonic-clonic seizure significantly decreased in the PS group compared to the control pups. Number and duration of tonic-clonic seizures increas...Continue Reading

References

Mar 1, 1991·Physiology & Behavior·D Suchecki, J Palermo Neto
Apr 15, 1999·Annual Review of Neuroscience·B S McEwen
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Dec 19, 2002·Hormones and Behavior·Heather E EdwardsW McIntyre Burnham
Mar 1, 2006·BMC Bioinformatics·Joshua S YuanC Neal Stewart
Dec 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Alwin KlaassenJim Boulter
Dec 21, 2006·Advances in Pharmacology·Werner Sieghart
Sep 2, 2008·Neuropharmacology·Richard W Olsen, Werner Sieghart
Dec 5, 2008·Epilepsia·Marian Joëls
Dec 17, 2009·Journal of Neurochemistry·Kelly J SkilbeckTina Hinton
May 21, 2010·Epilepsy & Behavior : E&B·Mahzad Mehrzad Sadaghiani, Ehsan Saboory
Jun 17, 2010·Brain Research Reviews·Arnaud CharilSuzanne King
May 7, 2011·Developmental Psychobiology·Ramin AhmadzadehAli Asghar Pilehvarian
Sep 20, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ehsan SabooryShiva Roshan-Milani
Nov 1, 2011·Current Opinion in Neurobiology·Rochelle M HinesJamie Maguire
Sep 21, 2013·Epilepsy & Behavior : E&B·Peyman GholipoorJavid Fereidoni
Oct 15, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Elham TavassoliAli Kalantari Hesari
Oct 29, 2013·Annual Review of Pharmacology and Toxicology·Uwe Rudolph, Hanns Möhler
Mar 22, 2014·Current Opinion in Neurobiology·Kai KailaMartin Puskarjov
Jun 15, 2014·Frontiers in Neuroendocrinology·Benjamin G GunnDelia Belelli
Jun 18, 2014·Frontiers in Cellular Neuroscience·Jamie Maguire
Sep 10, 2014·Progress in Brain Research·Shinichi Hirose
Apr 22, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·N SaidA Tazi
Jun 10, 2015·Physiology & Behavior·Ehsan SabooryParia Hashemi
Jul 15, 2015·European Journal of Pharmacology·István LingFerenc A Antoni
Mar 14, 2017·Stress : the International Journal on the Biology of Stress·Elnaz NakhjiriDavod Khalafkhani

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Citations

Jul 25, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Fatemeh Aghighi BidgoliSayyed Alireza Talaei

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